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Literature summary for 2.3.3.10 extracted from

  • Scharnagl, H.; März, W.; Schliack, M.; Löser, R.; Gross, W.
    A novel assay of cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase activity using reversed-phase ion-pair chromatography: demonstration that Lifibrol (K12.148) modulates the enzyme activity (1995), J. Lipid Res., 36, 622-627.
    View publication on PubMed
Search for more literature for 2.3.3.10

Application

Application Comment Organism
medicine enzyme is of growing medical interest as it is highly regulated Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
cDNA cloned and sequenced Gallus gallus
cDNA cloned and sequenced Homo sapiens
cDNA cloned and sequenced Rattus norvegicus
cDNA cloned and sequenced Mesocricetus auratus

Inhibitors

Inhibitors Comment Organism Structure
Lifibrol
-
 Gallus gallus
Lifibrol
-
 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Gallus gallus 5829
-
cytosol
-
 Homo sapiens 5829
-
cytosol
-
 Rattus norvegicus 5829
-
cytosol
-
 Mesocricetus auratus 5829
-
mitochondrion
-
 Gallus gallus 5739
-
mitochondrion
-
 Homo sapiens 5739
-
mitochondrion
-
 Rattus norvegicus 5739
-
mitochondrion
-
 Bos taurus 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
53000
-
 SDS-PAGE Gallus gallus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + acetoacetyl-CoA + H2O Gallus gallus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
acetyl-CoA + acetoacetyl-CoA + H2O Cricetulus griseus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
acetyl-CoA + acetoacetyl-CoA + H2O Homo sapiens
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
acetyl-CoA + acetoacetyl-CoA + H2O Rattus norvegicus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
acetyl-CoA + acetoacetyl-CoA + H2O Bos taurus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
acetyl-CoA + acetoacetyl-CoA + H2O Mesocricetus auratus
-
 (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 ox
-
Cricetulus griseus
-
 chinese hamster
-
Gallus gallus
-
 chicken
-
Homo sapiens
-
 HepG2 cells
-
Mesocricetus auratus
-
 syrian hamster, golden hamster
-
Rattus norvegicus
-
 rat
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus
partially Gallus gallus

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland
-
 Homo sapiens
-
adrenal gland
-
 Rattus norvegicus
-
fibroblast
-
 Homo sapiens
-
liver
-
 Gallus gallus
-
liver
-
 Rattus norvegicus
-
liver
-
 Bos taurus
-
ovary
-
 Cricetulus griseus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0101
-
-
 Gallus gallus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + acetoacetyl-CoA + H2O
-
 Gallus gallus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
acetyl-CoA + acetoacetyl-CoA + H2O
-
 Cricetulus griseus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
acetyl-CoA + acetoacetyl-CoA + H2O
-
 Homo sapiens (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
acetyl-CoA + acetoacetyl-CoA + H2O
-
 Rattus norvegicus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
acetyl-CoA + acetoacetyl-CoA + H2O
-
 Bos taurus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?
acetyl-CoA + acetoacetyl-CoA + H2O
-
 Mesocricetus auratus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
 ?