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Literature summary for 2.3.3.10 extracted from

  • Miziorko, H.M.; Behnke, C.E.
    Active-site directed inhibition of 3-hydroxy-3-methylglutaryl coenzyme A synthase by 3-chloropropionyl coenzyme A (1985), Biochemistry, 34, 3174-3179.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
3-chloropropionyl-CoA
-
Gallus gallus
DL-3-hydroxy-3-methylglutaryl-CoA product inhibition Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Gallus gallus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + acetoacetyl-CoA + H2O Gallus gallus
-
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
chicken
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + acetoacetyl-CoA + H2O
-
Gallus gallus (S)-3-hydroxy-3-methylglutaryl-CoA + CoA
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.012
-
DL-3-hydroxy-3-methylglutaryl-CoA
-
Gallus gallus
0.015
-
3-chloropropionyl-CoA
-
Gallus gallus