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Literature summary for 2.3.3.10 extracted from
- Some properties of 3-hydroxy-3-methylglutaryl-coenzyme A synthase from ox liver (1978), Biochem. J., 173, 925-928.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| acetoacetyl-CoA | - |
Gallus gallus |  |
| CoA | - |
Bos taurus | |
| CoA | - |
Saccharomyces cerevisiae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.1 | - |
acetyl-CoA | - |
Gallus gallus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Saccharomyces cerevisiae | 5737 | - |
| cytoplasm | - |
Bos taurus | 5737 | - |
| cytoplasm | distinct mitochondrial and cytoplasmic forms | Gallus gallus | 5737 | - |
| mitochondrion | - |
Bos taurus | 5739 | - |
| mitochondrion | distinct mitochondrial and cytoplasmic forms | Gallus gallus | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 88000 | - |
gel filtration | Gallus gallus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + acetoacetyl-CoA + H2O | Saccharomyces cerevisiae | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
| acetyl-CoA + acetoacetyl-CoA + H2O | Bos taurus | - |
(S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
| acetyl-CoA + acetoacetyl-CoA + H2O | Gallus gallus | mitochondrial enzyme is involved in the synthesis of acetoacetate, cytoplasmic enzyme in that of mevalonate | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
ox | - |
| Gallus gallus | - |
chicken | - |
| Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Gallus gallus |
- |
Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Gallus gallus | - |
| liver | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + acetoacetyl-CoA + H2O | - |
Gallus gallus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
| acetyl-CoA + acetoacetyl-CoA + H2O | - |
Saccharomyces cerevisiae | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
| acetyl-CoA + acetoacetyl-CoA + H2O | - |
Bos taurus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
| acetyl-CoA + acetoacetyl-CoA + H2O | mitochondrial enzyme is involved in the synthesis of acetoacetate, cytoplasmic enzyme in that of mevalonate | Gallus gallus | (S)-3-hydroxy-3-methylglutaryl-CoA + CoA | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.012 | - |
acetoacetyl-CoA | - |
Gallus gallus | |
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