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Literature summary for 2.3.2.B17 extracted from

  • Yakobov, N.; Fischer, F.; Mahmoudi, N.; Saga, Y.; Grube, C.D.; Roy, H.; Senger, B.; Grob, G.; Tatematsu, S.; Yokokawa, D.; Mouyna, I.; Latge, J.-P.; Nakajima, H.; Kushiro, T.; Becker, H.D.
    RNA-dependent sterol aspartylation in fungi (2020), Proc. Natl. Acad. Sci. USA, 117, 14948-14957 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.2.B17

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + Asp + ergosterol Aspergillus oryzae
-
 AMP + diphosphate + ergosteryl-3beta-O-L-aspartate
-
 ?
ATP + Asp + ergosterol Aspergillus oryzae ATCC 42149
-
 AMP + diphosphate + ergosteryl-3beta-O-L-aspartate
-
 ?
ATP + Asp + tRNAAsn Aspergillus oryzae
-
 AMP + diphosphate + L-aspartyl-tRNAAsn
-
 ?
ATP + Asp + tRNAAsn Aspergillus oryzae ATCC 42149
-
 AMP + diphosphate + L-aspartyl-tRNAAsn
-
 ?
ergosterol + L-aspartyl-tRNAAsn Aspergillus oryzae
-
 ergosteryl-3beta-O-L-aspartate + tRNAAsn
-
 ?
ergosterol + L-aspartyl-tRNAAsn Aspergillus oryzae ATCC 42149
-
 ergosteryl-3beta-O-L-aspartate + tRNAAsn
-
 ?
additional information Aspergillus oryzae a bifunctional enzyme, ergosteryl-3beta-O-L-aspartate synthase ErdS, is responsible for synthesis of ergosteryl-3beta-O-L-aspartate. ErdS produces aspartyl-tRNAAsp, reaction of EC 6.1.1.12, and transfers aspartate from Asp-tRNAAsp onto ergosterol ?
-
-
additional information Aspergillus oryzae ATCC 42149 a bifunctional enzyme, ergosteryl-3beta-O-L-aspartate synthase ErdS, is responsible for synthesis of ergosteryl-3beta-O-L-aspartate. ErdS produces aspartyl-tRNAAsp, reaction of EC 6.1.1.12, and transfers aspartate from Asp-tRNAAsp onto ergosterol ?
-
-

Organism

Organism UniProt Comment Textmining
Aspergillus fumigatus Q4WKG3 cf. EC 6.1.1.12
-
Aspergillus fumigatus ATCC MYA-4609 Q4WKG3 cf. EC 6.1.1.12
-
Aspergillus oryzae Q2URG4 cf. EC 6.1.1.12
-
Aspergillus oryzae ATCC 42149 Q2URG4 cf. EC 6.1.1.12
-

Source Tissue

Source Tissue Comment Organism Textmining
mycelium
-
 Aspergillus oryzae
-
mycelium
-
 Aspergillus fumigatus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + Asp + ergosterol
-
 Aspergillus oryzae AMP + diphosphate + ergosteryl-3beta-O-L-aspartate
-
 ?
ATP + Asp + ergosterol
-
 Aspergillus fumigatus AMP + diphosphate + ergosteryl-3beta-O-L-aspartate
-
 ?
ATP + Asp + ergosterol
-
 Aspergillus fumigatus ATCC MYA-4609 AMP + diphosphate + ergosteryl-3beta-O-L-aspartate
-
 ?
ATP + Asp + ergosterol
-
 Aspergillus oryzae ATCC 42149 AMP + diphosphate + ergosteryl-3beta-O-L-aspartate
-
 ?
ATP + Asp + tRNAAsn
-
 Aspergillus oryzae AMP + diphosphate + L-aspartyl-tRNAAsn
-
 ?
ATP + Asp + tRNAAsn
-
 Aspergillus fumigatus AMP + diphosphate + L-aspartyl-tRNAAsn
-
 ?
ATP + Asp + tRNAAsn
-
 Aspergillus fumigatus ATCC MYA-4609 AMP + diphosphate + L-aspartyl-tRNAAsn
-
 ?
ATP + Asp + tRNAAsn
-
 Aspergillus oryzae ATCC 42149 AMP + diphosphate + L-aspartyl-tRNAAsn
-
 ?
ATP + L-aspartate + ergosterol
-
 Aspergillus oryzae AMP + diphosphate + ergosteryl-3beta-O-L-aspartate
-
 ?
ATP + L-aspartate + ergosterol
-
 Aspergillus oryzae ATCC 42149 AMP + diphosphate + ergosteryl-3beta-O-L-aspartate
-
 ?
ergosterol + L-aspartyl-tRNAAsn
-
 Aspergillus oryzae ergosteryl-3beta-O-L-aspartate + tRNAAsn
-
 ?
ergosterol + L-aspartyl-tRNAAsn
-
 Aspergillus fumigatus ergosteryl-3beta-O-L-aspartate + tRNAAsn
-
 ?
ergosterol + L-aspartyl-tRNAAsn
-
 Aspergillus fumigatus ATCC MYA-4609 ergosteryl-3beta-O-L-aspartate + tRNAAsn
-
 ?
ergosterol + L-aspartyl-tRNAAsn
-
 Aspergillus oryzae ATCC 42149 ergosteryl-3beta-O-L-aspartate + tRNAAsn
-
 ?
additional information a bifunctional enzyme, ergosteryl-3beta-O-L-aspartate synthase ErdS, is responsible for synthesis of ergosteryl-3beta-O-L-aspartate. ErdS produces aspartyl-tRNAAsp, reaction of EC 6.1.1.12, and transfers aspartate from Asp-tRNAAsp onto ergosterol Aspergillus oryzae ?
-
-
additional information a bifunctional enzyme, ergosteryl-3beta-O-L-aspartate synthase ErdS, is responsible for synthesis of ergosteryl-3beta-O-L-aspartate. ErdS produces aspartyl-tRNAAsp, reaction of EC 6.1.1.12, and transfers aspartate from Asp-tRNAAsp onto ergosterol Aspergillus fumigatus ?
-
-
additional information a bifunctional enzyme, ergosteryl-3beta-O-L-aspartate synthase ErdS, is responsible for synthesis of ergosteryl-3beta-O-L-aspartate. ErdS produces aspartyl-tRNAAsp, reaction of EC 6.1.1.12, and transfers aspartate from Asp-tRNAAsp onto ergosterol Aspergillus fumigatus ATCC MYA-4609 ?
-
-
additional information a bifunctional enzyme, ergosteryl-3beta-O-L-aspartate synthase ErdS, is responsible for synthesis of ergosteryl-3beta-O-L-aspartate. ErdS produces aspartyl-tRNAAsp, reaction of EC 6.1.1.12, and transfers aspartate from Asp-tRNAAsp onto ergosterol Aspergillus oryzae ATCC 42149 ?
-
-

Synonyms

Synonyms Comment Organism
AFUA_1g02570
-
 Aspergillus fumigatus
AO090005000838
-
 Aspergillus oryzae
DUF2156 domain protein
-
 Aspergillus oryzae
DUF2156 domain protein
-
 Aspergillus fumigatus
ErdS
-
 Aspergillus oryzae
ErdS
-
 Aspergillus fumigatus
ergosteryl-3beta-O-L-aspartate synthase
-
 Aspergillus oryzae
ergosteryl-3beta-O-L-aspartate synthase
-
 Aspergillus fumigatus

General Information

General Information Comment Organism
evolution ErdS corresponds to a unique fusion of an aspartyl-tRNA synthetase that produces aspartyl-tRNAAsp and of a Domain of Unknown Function 2156, which actually transfers aspartate from Asp-tRNAAsp onto ergosterol. The entire ergosteryl-3beta-O-L-aspartate synthesis/degradation pathway is conserved across higher fungi Aspergillus oryzae
evolution ErdS corresponds to a unique fusion of an aspartyl-tRNA synthetase that produces aspartyl-tRNAAsp and of a Domain of Unknown Function 2156, which actually transfers aspartate from Asp-tRNAAsp onto ergosterol. The entire ergosteryl-3beta-O-L-aspartate synthesis/degradation pathway is conserved across higher fungi Aspergillus fumigatus
physiological function ergosteryl-3beta-O-L-aspartate is a type of sterol conjugate, specific to fungi, that is produced by ErdS enzymes, through a tRNA-dependent process. Fusion of the AspRS and the transferase (DUF2156) domain is required for full activity. ErdS mutants grow normally on solid media. Removal of the Asp group from ergosteryl-3beta-O-L-aspartate is catalyzed by a second enzyme, ErdH, that is a ergosteryl-3beta-O-L-aspartate hydrolase participating in the turnover of the conjugated sterol in vivo Aspergillus fumigatus
physiological function ergosteryl-3beta-O-L-aspartate is a type of sterol conjugate, specific to fungi, that is produced by ErdSs enzymes, through a tRNA-dependent process. Fusion of the AspRS and the transferase (DUF2156) domain is required for full activity. ErdS mutants grow normally on solid media. Removal of the Asp group from ergosteryl-3beta-O-L-aspartate is catalyzed by a second enzyme, ErdH, that is a ergosteryl-3beta-O-L-aspartate hydrolase participating in the turnover of the conjugated sterol in vivo Aspergillus oryzae