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Literature summary for 2.3.2.8 extracted from
- Inactivation of arginyl-tRNA protein transferase by a bifunctional arsenoxide: Identification of residues proximal to the arsenoxide site (1995), Biochemistry, 34, 139-147.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Saccharomyces cerevisiae |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C315A | full enzyme activity | Saccharomyces cerevisiae |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| aminophenylarsenoxide | 50% inhibition at 0.0025 mM | Saccharomyces cerevisiae |  |
| N-ethylmaleimide | rapid inactivation at 0.2 mM | Saccharomyces cerevisiae | |
| p-[(bromoacetyl)amino]phenylarsenoxide | irreversible, potent inhibitor | Saccharomyces cerevisiae | |
| phenylarsenoxide | inhibition below 0.005 mM is fully reversed by excess dithiothreitol | Saccharomyces cerevisiae | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Saccharomyces cerevisiae | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 58000 | - |
SDS-PAGE | Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-arginyl-tRNAArg + acceptor protein | Saccharomyces cerevisiae | involved in ubiquitin mediated protein degradation | tRNAArg + L-arginyl-[acceptor protein] | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharomyces cerevisiae | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| homogeneity | Saccharomyces cerevisiae |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-arginyl-tRNAArg + acceptor protein | - |
Saccharomyces cerevisiae | tRNAArg + L-arginyl-[acceptor protein] | - |
? | |
| L-arginyl-tRNAArg + acceptor protein | involved in ubiquitin mediated protein degradation | Saccharomyces cerevisiae | tRNAArg + L-arginyl-[acceptor protein] | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0667 | - |
L-Arginyl-tRNA | - |
Saccharomyces cerevisiae | |
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Release 2023.1 (January 2023)
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