Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,2-di-O-palmitoyl-3-O-(6'-deoxy-6'-sulfo-D-glycopyranosyl)-glycerol | - |
Homo sapiens | |
1-O-linolyl-2-O-palmitoyl-3-O-(6'-deoxy-6'-sulfo-D-glucopyranosyl)-glycerol | - |
Homo sapiens | |
1-O-palmitoyl-2-O-linolenyl-3-O-(6'-deoxy-6'-sulfo-D-glucopyranosyl)-glycerol | - |
Homo sapiens | |
additional information | natural products from microalgae, such as Scenedesmus rubescens strain SAG 5.95, Scenedesmus producto-capitatus strain SAG 21.81, Scenedesmus accuminatus strain SAG 38.81, Scenedesmus pectinatus strain SAG 2003, Tetradesmus wisconsinensis strain SAG 3.99, and Eustigmatos magnus strain SAG 36.89, show potential against Alzheimers disease, sulfolipids are potent glutaminyl cyclase inhibitors. Mass spectrometric identification and analysis (high resolution ESI-FTIC-MS and UPLC-MS, UPLC/ESI-MSn measurements). The sulfolipids share common, necessary substructures with pharmacophore characteristics of known QC inhibitors | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutaminyl-peptide | Homo sapiens | - |
5-oxoprolyl-peptide + NH3 | - |
? | |
additional information | Homo sapiens | orexin A, gastrin, gonadotropin, TRH, MCP-1 to 4, FPP, fibronectin, and neurotensin are substrates of the enzyme | ? | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16769 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
central nervous system | - |
Homo sapiens | - |
corpus striatum | - |
Homo sapiens | - |
hippocampus | - |
Homo sapiens | - |
hypophysis | - |
Homo sapiens | - |
hypothalamus | - |
Homo sapiens | - |
thymus | - |
Homo sapiens | - |
thyroid gland | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutaminyl-7-amido-4-methylcoumarin | - |
Homo sapiens | pGlu-7-amido-4-methylcoumarin + NH3 | - |
? | |
L-glutaminyl-peptide | - |
Homo sapiens | 5-oxoprolyl-peptide + NH3 | - |
? | |
additional information | orexin A, gastrin, gonadotropin, TRH, MCP-1 to 4, FPP, fibronectin, and neurotensin are substrates of the enzyme | Homo sapiens | ? | - |
- |
Synonyms | Comment | Organism |
---|---|---|
glutaminyl cyclase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
30 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
assay at | Homo sapiens |
General Information | Comment | Organism |
---|---|---|
evolution | glutaminyl cyclases (QCs) belong to the class of acyl transferases. Different types of QCs are identified in bacteria, plants and animals, including mammalian tissues | Homo sapiens |
physiological function | glutaminyl cyclases (QCs) catalyze the intramolecular cyclization of N-terminal L-glutamine residues of peptides and proteins into pyroglutamic acid (5-oxo-prolyl, pGlu, pE) releasing ammonia, as well as the intramolecular cyclization of N-terminal glutamate residues into pyroglutamic acid. Such a type of post-translational modification stabilizes the peptides and proteins, protects them from proteolytic degradation, and can be important for their biological activity | Homo sapiens |