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Literature summary for 2.3.2.5 extracted from

  • Adamson, S.W.; Browning, R.E.; Chao, C.C.; Bateman, R.C.; Ching, W.M.; Karim, S.
    Molecular characterization of tick salivary gland glutaminyl cyclase (2013), Insect Biochem. Mol. Biol., 43, 781-793.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.2.5

Metals/Ions

Metals/Ions Comment Organism Structure
Zn2+ contains zinc Ixodes scapularis
Zn2+ contains zinc Amblyomma maculatum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-glutaminyl-peptide Ixodes scapularis
-
 5-oxoprolyl-peptide + NH3
-
 ?
L-glutaminyl-peptide Amblyomma maculatum
-
 5-oxoprolyl-peptide + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Amblyomma maculatum G3MGU0
-
-
Ixodes scapularis B7QK46
-
-

Source Tissue

Source Tissue Comment Organism Textmining
saliva
-
 Ixodes scapularis
-
saliva
-
 Amblyomma maculatum
-
salivary gland
-
 Ixodes scapularis
-
salivary gland
-
 Amblyomma maculatum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Glu-2-naphthylamide
-
 Ixodes scapularis 5-oxo-L-prolyl-2-naphthylamide + NH3
-
 ?
L-Glu-2-naphthylamide
-
 Amblyomma maculatum 5-oxo-L-prolyl-2-naphthylamide + NH3
-
 ?
L-glutaminyl-peptide
-
 Ixodes scapularis 5-oxoprolyl-peptide + NH3
-
 ?
L-glutaminyl-peptide
-
 Amblyomma maculatum 5-oxoprolyl-peptide + NH3
-
 ?

Synonyms

Synonyms Comment Organism
glutaminyl cyclase
-
 Ixodes scapularis
glutaminyl cyclase
-
 Amblyomma maculatum

Expression

Organism Comment Expression
Ixodes scapularis the enzyme is upregulated during the bloodmeal up
Amblyomma maculatum the enzyme is upregulated during the bloodmeal up

General Information

General Information Comment Organism
malfunction knockdown of enzyme-transcript results in lower enzymatic activity, and small, unviable egg masses Ixodes scapularis
malfunction knockdown of enzyme-transcript results in lower enzymatic activity, and small, unviable egg masses Amblyomma maculatum