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Literature summary for 2.3.2.5 extracted from
- Cloning, expression, characterization, and crystallization of a glutaminyl cyclase from human bone marrow: a single zinc metalloenzyme (2005), Protein Expr. Purif., 43, 65-72.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| hanging-drop vapor diffusion | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-Benzylimidazole | 0.14 mM, 58% inhibition | Homo sapiens |  |
| 3,5-diamino-1,2-S4-triazole | 0.14 mM, 10% inhibition | Homo sapiens | |
| 3-Amino-1,2,4-triazole | 0.14 mM, 15% inhibition | Homo sapiens | |
| 4-phenyl-1,2,4-triazoleine-3,5-dione | 0.14 mM, 22% inhibition | Homo sapiens | |
| 5-(methylthio)-1-H-tetrazole | 0.14 mM, 11% inhibition | Homo sapiens | |
| ethyl-1H-tetrazole-4-acetate | 0.14 mM, 9% inhibition | Homo sapiens | |
| N-omega-acetylhistamine | 0.14 mM, 33% inhibition | Homo sapiens | |
| nitron | 0.14 mM, 39% inhibition | Homo sapiens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.6 | - |
Gln-Gln | - |
Homo sapiens | |
| 4.1 | - |
Gln-tert-butyl ester | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zinc | contains one zinc ion per protein molecule | Homo sapiens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 37520 | - |
mass spectrometry analysis | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| bone marrow | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Gln-Gln | - |
Homo sapiens | pyroglutamyl-Gln + NH3 | - |
? | |
| Gln-His-Pro | - |
Homo sapiens | pyroglutamyl-His-Pro | - |
? | |
| Gln-tert-butyl ester | - |
Homo sapiens | pyroglutamyl-tert-butyl ester + NH3 | - |
? | |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 8.6 | - |
Gln-Gln | - |
Homo sapiens | |
| 20.9 | - |
Gln-tert-butyl ester | - |
Homo sapiens | |
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