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Literature summary for 2.3.2.5 extracted from

  • Schilling, S.; Hoffmann, T.; Manhart, S.; Hoffmann, M.; Demuth, H.U.
    Glutaminyl cyclases unfold glutamyl cyclase activity under mild acid conditions (2004), FEBS Lett., 563, 191-196.
    View publication on PubMed
Search for more literature for 2.3.2.5

Inhibitors

Inhibitors Comment Organism Structure
benzimidazole
-
 Carica papaya
benzimidazole
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.019
-
 glucagon(3-29) pH 6.0, 30°C, 1% DMSO Homo sapiens
0.087
-
 Gln(3)-amyloid-beta peptide 3-11 amide pH 6.0, 30°C, in absence of DMSO Homo sapiens
0.089
-
 Gln(3)-amyloid-beta peptide 3-40 amide pH 6.0, 30°C, 1% DMSO Homo sapiens
0.155
-
 Gln(3)-amyloid-beta peptide 3-11 amide pH 6.0, 30°C, 1% DMSO Homo sapiens
0.162
-
 Gln(3)-amyloid-beta peptide 3-21 amide pH 6.0, 30°C, 1% DMSO Homo sapiens

Organism

Organism UniProt Comment Textmining
Carica papaya
-
-
-
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gln(3)-amyloid-beta peptide 3-11 amide
-
 Homo sapiens ?
-
 ?
Gln(3)-amyloid-beta peptide 3-21 amide
-
 Homo sapiens ?
-
 ?
Gln(3)-amyloid-beta peptide 3-40 amide
-
 Homo sapiens ?
-
 ?
Gln-2-naphthylamide
-
 Carica papaya pyroglutamyl-2-naphthylamide + NH3
-
 ?
Glu-2-naphthylamide
-
 Carica papaya ?
-
 ?
glucagon(3-29)
-
 Homo sapiens ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
10
-
 glucagon(3-29) pH 6.0, 30°C, 1% DMSO Homo sapiens
40
-
 Gln(3)-amyloid-beta peptide 3-40 amide pH 6.0, 30°C, 1% DMSO Homo sapiens
41.4
-
 Gln(3)-amyloid-beta peptide 3-11 amide pH 6.0, 30°C, 1% DMSO Homo sapiens
55
-
 Gln(3)-amyloid-beta peptide 3-11 amide pH 6.0, 30°C, in absence of DMSO Homo sapiens
62
-
 Gln(3)-amyloid-beta peptide 3-21 amide pH 6.0, 30°C, 1% DMSO Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 cyclization of glutamic acid Carica papaya
8
-
 cyclization of glutamine Carica papaya