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Literature summary for 2.3.2.5 extracted from

  • Schilling, S.; Manhart, S.; Hoffmann, T.; Ludwig, H.H.; Wasternack, C.; Demuth, H.U.
    Substrate specificity of glutaminyl cyclases from plants and animals (2003), Biol. Chem., 384, 1583-1592.
    View publication on PubMed
Search for more literature for 2.3.2.5

Inhibitors

Inhibitors Comment Organism Structure
Gln-tert-butyl ester
-
 Carica papaya
Gln-tert-butyl ester
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.023
-
 [Gln1]-neurotensin pH 8.0, 30°C Carica papaya
0.031
-
 [Gln1]-gastrin pH 8.0, 30°C Homo sapiens
0.032
-
 N1-naphthalen-2-yl-L-glutamamide pH 8.0, 30°C, 0.5 M KCl Carica papaya
0.033
-
 [Gln1]-gastrin pH 8.0, 30°C Carica papaya
0.034
-
 Gln-Lys-Arg-Leu-NH2 pH 8.0, 30°C, 0.5 M KCl Homo sapiens
0.037
-
 [Gln1]-neurotensin pH 8.0, 30°C Homo sapiens
0.038
-
 Gln-beta-naphthylamine pH 8.0, 30°C Carica papaya
0.039
-
 Gln-Glu-Ala-Phe-NH2 pH 8.0, 30°C Homo sapiens
0.041
-
 Gln-Gln-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
0.042
-
 Gln 7-amido-4-methylcoumarin pH 8.0, 30°C Carica papaya
0.044
-
 Gln-Gln pH 8.0, 30°C Carica papaya
0.045
-
 Gln-Gln-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
0.047
-
 Gln-Glu-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
0.05
-
 Gln-Trp-Ala-NH2 pH 8.0, 30°C Homo sapiens
0.053
-
 [Gln1]-gonadotropin releasing-hormone pH 8.0, 30°C Homo sapiens
0.053
-
 Gln-Lys-Arg-Leu-NH2 pH 8.0, 30°C, 0.5 M KCl Carica papaya
0.054
-
 Gln-Lys-Arg-Leu-NH2 pH 8.0, 30°C Homo sapiens
0.054
-
 [Gln1]-gonadotropin releasing-hormone pH 8.0, 30°C Carica papaya
0.054
-
 Gln-7-amido-4-methylcoumarin pH 8.0, 30°C Homo sapiens
0.055
-
 Gln-Glu-Asp-Leu-NH2 pH 8.0, 30°C Homo sapiens
0.055
-
 Gln-Ser-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
0.055
-
 Gln-Arg-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
0.056
-
 Gln-Trp-Ala-NH2 pH 8.0, 30°C, 0.5 M KCl Homo sapiens
0.061
-
 Gln-Glu-Asp-Leu-NH2 pH 8.0, 30°C, 0.5 M KCl Homo sapiens
0.063
-
 Gln-Tyr-Ala pH 8.0, 30°C Carica papaya
0.063
-
 N1-naphthalen-2-yl-L-glutamamide pH 8.0, 30°C, 0.5 M KCl Homo sapiens
0.065
-
 Gln-Ala-Ala-Ala-Ala-NH2 pH 8.0, 30°C Homo sapiens
0.065
-
 Gln-Arg-Gly-Ile-NH2 pH 8.0, 30°C, 0.5 M KCl Carica papaya
0.068
-
 Gln-His-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
0.069
-
 Gln-Phe-Ala-NH2 pH 8.0, 30°C Homo sapiens
0.069
-
 Gln-Glu-Tyr-Ala-NH2 pH 8.0, 30°C Homo sapiens
0.07
-
 Gln-beta-naphthylamide pH 8.0, 30°C Homo sapiens
0.072
-
 Gln-Trp-Ala-NH2 pH 8.0, 30°C, 0.5 M KCl Carica papaya
0.077
-
 Gln-Glu-Ala-Ala-NH2 pH 8.0, 30°C Homo sapiens
0.078
-
 Gln-Trp-Ala-NH2 pH 8.0, 30°C Carica papaya
0.079
-
 Gln-Glu-Tyr-NH2 pH 8.0, 30°C Homo sapiens
0.079
-
 Gln-Ala-Ala-Ser-Ala-Ala-NH2 pH 8.0, 30°C Homo sapiens
0.081
-
 Gln-Glu-Ala-Phe-NH2 pH 8.0, 30°C Carica papaya
0.087
-
 [Gln1]-fertilization promoting peptide pH 8.0, 30°C Homo sapiens
0.087
-
 Gln-Ala-Ala-NH2 pH 8.0, 30°Cl Homo sapiens
0.09
-
 [Gln1]-thyrotropin releasing-hormone pH 8.0, 30°C Homo sapiens
0.091
-
 Gln-Arg-Gly-Ile-NH2 pH 8.0, 30°C, 0.5 M KCl Homo sapiens
0.092
-
 Gln-His-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
0.094
-
 Gln-Glu pH 8.0, 30°C, 0.5 M KCl Carica papaya
0.094
-
 Gln-Glu-Asp-Leu-NH2 pH 8.0, 30°C, 0.5 M KCl Carica papaya
0.1
-
 Gln-Glu-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
0.101
-
 Gln-Tyr-Ala pH 8.0, 30°C Homo sapiens
0.102
-
 Gln-Glu-Ala-Ala-NH2 pH 8.0, 30°C Carica papaya
0.103
-
 Gln-Glu-Tyr-NH2 pH 8.0, 30°C Carica papaya
0.106
-
 Gln-Glu pH 8.0, 30°C Carica papaya
0.107
-
 Gln-Glu-Asp-Leu-NH2 pH 8.0, 30°C Carica papaya
0.111
-
 Gln-Phe-Ala-NH2 pH 8.0, 30°C Carica papaya
0.113
-
 Gln-Glu-Tyr-Ala-NH2 pH 8.0, 30°C Carica papaya
0.118
-
 Gln-Lys-Arg-Leu-NH2 pH 8.0, 30°C Carica papaya
0.123
-
 Gln-Arg-Gly-Ile-NH2 pH 8.0, 30°C Carica papaya
0.124
-
 Gln-Arg-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
0.13
-
 Gln-Gly-Pro pH 8.0, 30°C Homo sapiens
0.135
-
 Gln-Ser-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
0.143
-
 Gln-Arg-Gly-Ile-NH2 pH 8.0, 30°C Homo sapiens
0.143
-
 Gln-Ala pH 8.0, 30°C, 0.5 M KCl Carica papaya
0.148
-
 Gln-Gln pH 8.0, 30°C Homo sapiens
0.149
-
 Gln-Pro-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
0.151
-
 [Gln1]-fertilization promoting peptide pH 8.0, 30°C Carica papaya
0.153
-
 Gln-Asn-Gly-Ile-NH2 pH 8.0, 30°C Carica papaya
0.158
-
 Gln-Ala pH 8.0, 30°C Carica papaya
0.164
-
 Gln-Ala-Ala-NH2 pH 8.0, 30°Cl Carica papaya
0.172
-
 Gln-Asn-Gly-Ile-NH2 pH 8.0, 30°C Homo sapiens
0.196
-
 Gln-Val pH 8.0, 30°C Homo sapiens
0.197
-
 Gln-Ala-Ala-Ala-Ala-NH2 pH 8.0, 30°C Carica papaya
0.211
-
 Gln-Tyr pH 8.0, 30°C Homo sapiens
0.216
-
 Gln-Ala-Ala-Ser-Ala-Ala-NH2 pH 8.0, 30°C Carica papaya
0.223
-
 Gln-tert-butyl ester pH 8.0, 30°C Carica papaya
0.232
-
 Gln-Ala pH 8.0, 30°C Homo sapiens
0.247
-
 Gln-Gly pH 8.0, 30°C Homo sapiens
0.333
-
 Gln-Gly-Pro pH 8.0, 30°C Carica papaya
0.357
-
 Gln-Ala pH 8.0, 30°C, 0.5 M KCl Homo sapiens
0.359
-
 Gln-Glu pH 8.0, 30°C Homo sapiens
0.401
-
 Gln-NH2 pH 8.0, 30°C, 0.5 M KCl Homo sapiens
0.409
-
 Gln-NH2 pH 8.0, 30°C Homo sapiens
0.433
-
 Gln-NH2 pH 8.0, 30°C Carica papaya
0.446
-
 Gln-NH2 pH 8.0, 30°C, 0.5 M KCl Carica papaya
0.607
-
 Gln-Glu pH 8.0, 30°C, 0.5 M KCl Homo sapiens
0.641
-
 Gln-Gly pH 8.0, 30°C Carica papaya
1.235
-
 Gln-tert-butyl ester pH 8.0, 30°C Homo sapiens
18.89
-
 Gln-Pro-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
additional information substrate specificity for substrates with uncharged backbone and for Gln-Ala and Gln-Glu, does not change significantly by salt addition. With the positively charged substrates Gln-Arg-Gly-Ile-NH2 and Gln-Lys-Arg-Leu-NH2 addition of salt reveals a positive effect on catalysis Carica papaya
additional information substrate specificity for substrates with uncharged backbone does not change significantly by salt addition. For substrates such as Gln-Ala and Gln-Glu, addition of KCl decreases specificity. With the positively charged substrates Gln-Arg-Gly-Ile-NH2 and Gln-Lys-Arg-Leu-NH2 addition of salt reveals a positive effect on catalysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme may play a key role in posttranslational modification ?
-
 ?
additional information Carica papaya the enzyme may play a key role in posttranslational modification ?
-
 ?

Organism

Organism UniProt Comment Textmining
Carica papaya
-
-
-
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gln-7-amido-4-methylcoumarin
-
 Homo sapiens L-pyroglutamyl-4-methylcoumarin-7-amide + NH3
-
 ?
Gln-7-amido-4-methylcoumarin
-
 Carica papaya pyroglutamic acid-7-amido-4-methylcoumarin + NH3
-
 ?
Gln-Ala
-
 Homo sapiens pyroglutamic acid-Ala + NH3
-
 ?
Gln-Ala
-
 Carica papaya pyroglutamic acid-Ala + NH3
-
 ?
Gln-Ala-Ala-Ala-Ala-NH2
-
 Homo sapiens pyroglutamic acid-Ala-Ala-Ala-Ala-NH2 + NH3
-
 ?
Gln-Ala-Ala-Ala-Ala-NH2
-
 Carica papaya pyroglutamic acid-Ala-Ala-Ala-Ala-NH2 + NH3
-
 ?
Gln-Ala-Ala-NH2
-
 Homo sapiens pyroglutamic acid-Ala-Ala-NH2 + NH3
-
 ?
Gln-Ala-Ala-NH2
-
 Carica papaya pyroglutamic acid-Ala-Ala-NH2 + NH3
-
 ?
Gln-Ala-Ala-Ser-Ala-Ala-NH2
-
 Homo sapiens pyroglutamic acid-Ala-Ala-Ser-Ala-Ala-NH2 + NH3
-
 ?
Gln-Ala-Ala-Ser-Ala-Ala-NH2
-
 Carica papaya pyroglutamic acid-Ala-Ala-Ser-Ala-Ala-NH2 + NH3
-
 ?
Gln-Arg-Gly-Ile-NH2
-
 Homo sapiens pyroglutamic acid-Arg-Gly-Ile-NH2 + NH3
-
 ?
Gln-Arg-Gly-Ile-NH2
-
 Carica papaya pyroglutamic acid-Arg-Gly-Ile-NH2 + NH3
-
 ?
Gln-Arg-Tyr-Phe-NH2
-
 Homo sapiens pyroglutamic acid-Arg-Tyr-Phe-NH2 + NH3
-
 ?
Gln-Arg-Tyr-Phe-NH2
-
 Carica papaya pyroglutamic acid-Arg-Tyr-Phe-NH2 + NH3
-
 ?
Gln-Asn-Gly-Ile-NH2
-
 Homo sapiens pyroglutamic acid-Asn-Gly-Ile-NH2 + NH3
-
 ?
Gln-Asn-Gly-Ile-NH2
-
 Carica papaya pyroglutamic acid-Asn-Gly-Ile-NH2 + NH3
-
 ?
Gln-beta-naphthylamide
-
 Homo sapiens pyroglutamic acid-beta-naphthylamide + NH3
-
 ?
Gln-beta-naphthylamide
-
 Carica papaya pyroglutamic acid-beta-naphthylamine + NH3
-
 ?
Gln-Gln
-
 Homo sapiens pyroglutamic acid-Gln + NH3
-
 ?
Gln-Gln
-
 Carica papaya pyroglutamic acid-Gln + NH3
-
 ?
Gln-Gln-Tyr-Phe-NH2
-
 Homo sapiens pyroglutamic acid-Gln-Tyr-Phe-NH2 + NH3
-
 ?
Gln-Gln-Tyr-Phe-NH2
-
 Carica papaya pyroglutamic acid-Gln-Tyr-Phe-NH2 + NH3
-
 ?
Gln-Glu
-
 Homo sapiens pyroglutamic acid-Glu + NH3
-
 ?
Gln-Glu
-
 Carica papaya pyroglutamic acid-Glu + NH3
-
 ?
Gln-Glu-Ala-Ala-NH2
-
 Homo sapiens pyroglutamic acid-Glu-Ala-Ala-NH2 + NH3
-
 ?
Gln-Glu-Ala-Ala-NH2
-
 Carica papaya pyroglutamic acid-Glu-Ala-Ala-NH2 + NH3
-
 ?
Gln-Glu-Ala-Phe-NH2
-
 Homo sapiens pyroglutamic acid-Glu-Ala-Phe-NH2 + NH3
-
 ?
Gln-Glu-Ala-Phe-NH2
-
 Carica papaya pyroglutamic acid-Glu-Ala-Phe-NH2 + NH3
-
 ?
Gln-Glu-Asp-Leu-NH2
-
 Homo sapiens pyroglutamic acid-Glu-Asp-Leu-NH2 + NH3
-
 ?
Gln-Glu-Asp-Leu-NH2
-
 Carica papaya pyroglutamic acid-Glu-Asp-Leu-NH2 + NH3
-
 ?
Gln-Glu-Tyr-Ala-NH2
-
 Homo sapiens pyroglutamic acid-Glu-Tyr-Ala-NH2 + NH3
-
 ?
Gln-Glu-Tyr-Ala-NH2
-
 Carica papaya pyroglutamic acid-Glu-Tyr-Ala-NH2 + NH3
-
 ?
Gln-Glu-Tyr-NH2
-
 Homo sapiens pyroglutamic acid-Glu-Tyr-NH2 + NH3
-
 ?
Gln-Glu-Tyr-NH2
-
 Carica papaya pyroglutamic acid-Glu-Tyr-NH2 + NH3
-
 ?
Gln-Glu-Tyr-Phe-NH2
-
 Homo sapiens pyroglutamic acid-Glu-Tyr-Phe-NH2 + NH3
-
 ?
Gln-Glu-Tyr-Phe-NH2
-
 Carica papaya pyroglutamic acid-Glu-Tyr-Phe-NH2 + NH3
-
 ?
Gln-Gly
-
 Homo sapiens pyroglutamic acid-Gly + NH3
-
 ?
Gln-Gly
-
 Carica papaya pyroglutamic acid-Gly + NH3
-
 ?
Gln-Gly-Pro
-
 Homo sapiens pyroglutamic acid-Gly-Pro + NH3
-
 ?
Gln-Gly-Pro
-
 Carica papaya pyroglutamic acid-Gly-Pro + NH3
-
 ?
Gln-His-Tyr-Phe-NH2
-
 Homo sapiens pyroglutamic acid-His-Tyr-Phe-NH2 + NH3
-
 ?
Gln-His-Tyr-Phe-NH2
-
 Carica papaya pyroglutamic acid-His-Tyr-Phe-NH2 + NH3
-
 ?
Gln-Lys-Arg-Leu-NH2
-
 Homo sapiens pyroglutamic acid-Lys-Arg-Leu-NH2 + NH3
-
 ?
Gln-Lys-Arg-Leu-NH2
-
 Carica papaya pyroglutamic acid-Lys-Arg-Leu-NH2 + NH3
-
 ?
Gln-Phe-Ala-NH2
-
 Homo sapiens pyroglutamic acid-Phe-Ala-NH2 + NH3
-
 ?
Gln-Phe-Ala-NH2
-
 Carica papaya pyroglutamic acid-Phe-Ala-NH2 + NH3
-
 ?
Gln-Pro-Tyr-Phe-NH2
-
 Homo sapiens pyroglutamic acid-Pro-Tyr-Phe-NH2 + NH3
-
 ?
Gln-Pro-Tyr-Phe-NH2
-
 Carica papaya pyroglutamic acid-Pro-Tyr-Phe-NH2 + NH3
-
 ?
Gln-Ser-Tyr-Phe-NH2
-
 Homo sapiens pyroglutamic acid-Ser-Tyr-Phe-NH2 + NH3
-
 ?
Gln-Ser-Tyr-Phe-NH2
-
 Carica papaya pyroglutamic acid-Ser-Tyr-Phe-NH2 + NH3
-
 ?
Gln-tert-butyl ester
-
 Homo sapiens pyroglutamyl-tert-butyl ester + NH3
-
 ?
Gln-tert-butyl ester
-
 Carica papaya pyroglutamyl-tert-butyl ester + NH3
-
 ?
Gln-Trp-Ala-NH2
-
 Homo sapiens pyroglutamic acid-Trp-Ala-NH2 + NH3
-
 ?
Gln-Trp-Ala-NH2
-
 Carica papaya pyroglutamic acid-Trp-Ala-NH2 + NH3
-
 ?
Gln-Tyr
-
 Homo sapiens pyroglutamic acid-Tyr + NH3
-
 ?
Gln-Tyr-Ala
-
 Homo sapiens pyroglutamic acid-Tyr-Ala + NH3
-
 ?
Gln-Tyr-Ala
-
 Carica papaya pyroglutamic acid-Tyr-Ala + NH3
-
 ?
Gln-Val
-
 Homo sapiens pyroglutamic acid-Val + NH3
-
 ?
L-Gln-NH2
-
 Homo sapiens L-pyroglutamyl amide + NH3
-
 ?
L-Gln-NH2
-
 Carica papaya L-pyroglutamyl amide + NH3
-
 ?
additional information the enzyme may play a key role in posttranslational modification Homo sapiens ?
-
 ?
additional information the enzyme may play a key role in posttranslational modification Carica papaya ?
-
 ?
[Gln1]-fertilization promoting peptide
-
 Homo sapiens [pyroglutamyl]-fertilization promoting peptide + NH3
-
 ?
[Gln1]-fertilization promoting peptide
-
 Carica papaya [pyroglutamyl]-fertilization promoting peptide + NH3
-
 ?
[Gln1]-gastrin
-
 Homo sapiens [pyroglutamyl]-gastrin + NH3
-
 ?
[Gln1]-gastrin
-
 Carica papaya [pyroglutamyl]-gastrin + NH3
-
 ?
[Gln1]-gonadotropin releasing-hormone
-
 Homo sapiens [pyroglutamyl]-gonadotropin releasing-hormone + NH3
-
 ?
[Gln1]-gonadotropin releasing-hormone
-
 Carica papaya [pyroglutamyl]-gonadotropin releasing-hormone + NH3
-
 ?
[Gln1]-neurotensin
-
 Homo sapiens [pyroglutamyl]-neurotensin + NH3
-
 ?
[Gln1]-neurotensin
-
 Carica papaya [pyroglutamyl]-neurotensin + NH3
-
 ?
[Gln1]-thyrotropin releasing-hormone
-
 Homo sapiens [pyroglutamyl]-thyrotropin releasing-hormone + NH3
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
5.3
-
 Gln-7-amido-4-methylcoumarin pH 8.0, 30°C Homo sapiens
6.7
-
 Gln-tert-butyl ester pH 8.0, 30°C Homo sapiens
12.2
-
 Gln-NH2 pH 8.0, 30°C, 0.5 M KCl Homo sapiens
12.8
-
 Gln-NH2 pH 8.0, 30°C Homo sapiens
13.2
-
 Gln-Gly pH 8.0, 30°C Homo sapiens
17.2
-
 Gln-Val pH 8.0, 30°C Homo sapiens
18.8
-
 Gln-Pro-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
18.9
-
 Gln-Glu pH 8.0, 30°C, 0.5 M KCl Homo sapiens
20
-
 N1-naphthalen-2-yl-L-glutamamide pH 8.0, 30°C, 0.5 M KCl Homo sapiens
20.6
-
 Gln-beta-naphthylamide pH 8.0, 30°C Homo sapiens
20.7
-
 Gln-Gln pH 8.0, 30°C Homo sapiens
24.7
-
 Gln-Glu pH 8.0, 30°C Homo sapiens
25.3
-
 Gln-Gly-Pro pH 8.0, 30°C Homo sapiens
29.6
-
 Gln-Arg-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
29.8
-
 Gln-Arg-Gly-Ile-NH2 pH 8.0, 30°C, 0.5 M KCl Homo sapiens
31.6
-
 [Gln1]-gastrin pH 8.0, 30°C Carica papaya
31.6
-
 Gln-Lys-Arg-Leu-NH2 pH 8.0, 30°C, 0.5 M KCl Homo sapiens
31.7
-
 Gln-Pro-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
33.4
-
 Gln-Lys-Arg-Leu-NH2 pH 8.0, 30°C Homo sapiens
33.5
-
 Gln-Arg-Gly-Ile-NH2 pH 8.0, 30°C Homo sapiens
37.7
-
 [Gln1]-neurotensin pH 8.0, 30°C Carica papaya
37.7
-
 [Gln1]-fertilization promoting peptide pH 8.0, 30°C Carica papaya
39
-
 Gln-Glu-Ala-Phe-NH2 pH 8.0, 30°C Homo sapiens
39.4
-
 Gln 7-amido-4-methylcoumarin pH 8.0, 30°C Carica papaya
41.4
-
 Gln-Gln-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
41.7
-
 Gln-Gly-Pro pH 8.0, 30°C Carica papaya
42.1
-
 Gln-Glu-Tyr-Ala-NH2 pH 8.0, 30°C Homo sapiens
43.2
-
 Gln-Gln pH 8.0, 30°C Carica papaya
44.4
-
 Gln-Glu pH 8.0, 30°C, 0.5 M KCl Carica papaya
44.7
-
 Gln-Glu-Tyr-Ala-NH2 pH 8.0, 30°C Carica papaya
44.8
-
 Gln-NH2 pH 8.0, 30°C Carica papaya
45.1
-
 Gln-Glu-Tyr-NH2 pH 8.0, 30°C Homo sapiens
45.2
-
 Gln-NH2 pH 8.0, 30°C, 0.5 M KCl Carica papaya
45.6
-
 Gln-Glu-Asp-Leu-NH2 pH 8.0, 30°C, 0.5 M KCl Homo sapiens
45.8
-
 Gln-Gly pH 8.0, 30°C Carica papaya
45.8
-
 Gln-Glu-Asp-Leu-NH2 pH 8.0, 30°C Homo sapiens
46
-
 Gln-Glu-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
46
-
 Gln-Glu-Ala-Ala-NH2 pH 8.0, 30°C Homo sapiens
47
-
 Gln-Trp-Ala-NH2 pH 8.0, 30°C Homo sapiens
47.2
-
 N1-naphthalen-2-yl-L-glutamamide pH 8.0, 30°C, 0.5 M KCl Carica papaya
47.6
-
 Gln-Ala pH 8.0, 30°C, 0.5 M KCl Homo sapiens
48.2
-
 Gln-Lys-Arg-Leu-NH2 pH 8.0, 30°C Carica papaya
48.4
-
 Gln-Arg-Gly-Ile-NH2 pH 8.0, 30°C, 0.5 M KCl Carica papaya
48.5
-
 Gln-Glu-Ala-Phe-NH2 pH 8.0, 30°C Carica papaya
48.8
-
 [Gln1]-neurotensin pH 8.0, 30°C Homo sapiens
48.9
-
 Gln-Arg-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
49.2
-
 Gln-Arg-Gly-Ile-NH2 pH 8.0, 30°C Carica papaya
49.4
-
 Gln-tert-butyl ester pH 8.0, 30°C Carica papaya
50
-
 Gln-Trp-Ala-NH2 pH 8.0, 30°C, 0.5 M KCl Homo sapiens
50.3
-
 Gln-Glu pH 8.0, 30°C Carica papaya
51.4
-
 Gln-Asn-Gly-Ile-NH2 pH 8.0, 30°C Carica papaya
51.4
-
 Gln-beta-naphthylamine pH 8.0, 30°C Carica papaya
52.8
-
 Gln-Ser-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
52.9
-
 Gln-Gln-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
53.6
-
 Gln-Glu-Tyr-NH2 pH 8.0, 30°C Carica papaya
53.6
-
 Gln-Glu-Asp-Leu-NH2 pH 8.0, 30°C, 0.5 M KCl Carica papaya
53.7
-
 Gln-Glu-Ala-Ala-NH2 pH 8.0, 30°C Carica papaya
54.1
-
 [Gln1]-gastrin pH 8.0, 30°C Homo sapiens
54.6
-
 Gln-Glu-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
55.3
-
 Gln-Ala-Ala-Ser-Ala-Ala-NH2 pH 8.0, 30°C Homo sapiens
55.4
-
 Gln-His-Tyr-Phe-NH2 pH 8.0, 30°C Homo sapiens
56.6
-
 Gln-Asn-Gly-Ile-NH2 pH 8.0, 30°C Homo sapiens
57.2
-
 Gln-Ala pH 8.0, 30°C Homo sapiens
58.1
-
 Gln-Lys-Arg-Leu-NH2 pH 8.0, 30°C, 0.5 M KCl Carica papaya
58.5
-
 Gln-Glu-Asp-Leu-NH2 pH 8.0, 30°C Carica papaya
60.5
-
 Gln-Ala-Ala-Ala-Ala-NH2 pH 8.0, 30°C Homo sapiens
64.9
-
 Gln-Ser-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
68.1
-
 Gln-Ala pH 8.0, 30°C, 0.5 M KCl Carica papaya
69.2
-
 [Gln1]-gonadotropin releasing-hormone pH 8.0, 30°C Homo sapiens
69.6
-
 [Gln1]-fertilization promoting peptide pH 8.0, 30°C Homo sapiens
69.8
-
 Gln-Ala pH 8.0, 30°C Carica papaya
72.4
-
 [Gln1]-gonadotropin releasing-hormone pH 8.0, 30°C Carica papaya
74.6
-
 Gln-Ala-Ala-Ala-Ala-NH2 pH 8.0, 30°C Carica papaya
75.9
-
 Gln-His-Tyr-Phe-NH2 pH 8.0, 30°C Carica papaya
76.3
-
 Gln-Ala-Ala-NH2 pH 8.0, 30°C Homo sapiens
78.5
-
 Gln-Ala-Ala-Ser-Ala-Ala-NH2 pH 8.0, 30°C Carica papaya
82.8
-
 [Gln1]-thyrotropin releasing-hormone pH 8.0, 30°C Homo sapiens
83.2
-
 Gln-Ala-Ala-NH2 pH 8.0, 30°C Carica papaya
94
-
 Gln-Tyr pH 8.0, 30°C Homo sapiens
104
-
 Gln-Tyr-Ala pH 8.0, 30°C Carica papaya
109
-
 Gln-Phe-Ala-NH2 pH 8.0, 30°C Homo sapiens
125
-
 Gln-Tyr-Ala pH 8.0, 30°C Homo sapiens
132
-
 Gln-Phe-Ala-NH2 pH 8.0, 30°C Carica papaya
133
-
 Gln-Trp-Ala-NH2 pH 8.0, 30°C, 0.5 M KCl Carica papaya
151.8
-
 Gln-Trp-Ala-NH2 pH 8.0, 30°C Carica papaya

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.8 8
-
 Homo sapiens
7.8 8
-
 Carica papaya

pH Stability

pH Stability pH Stability Maximum Comment Organism
4
-
 30°C, 30 min, about 10% loss of activity Carica papaya
5 6 30°C, 30 min, about 30% loss of activity Carica papaya
5.5
-
 30°C, 30 min, about 70% loss of activity Homo sapiens
6
-
 30°C, 30 min, about 50% loss of activity Homo sapiens
6.5
-
 30°C, 30 min, about 40% loss of activity Homo sapiens
6.5 8 30°C, 30 min, about 10% loss of activity Carica papaya
7 9 30°C, 30 min, less than 20% loss of activity Homo sapiens
8.5
-
 30°C, 30 min, about 20% loss of activity Carica papaya
9 10 30°C, 30 min, about 15% loss of activity Carica papaya
9.5
-
 30°C, 30 min, about 50% loss of activity Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.97
-
 Gln-tert-butyl ester pH 8.0, 30°C, 0.5 M KCl Homo sapiens
1.2
-
 Gln-tert-butyl ester pH 8.0, 30°C Carica papaya
1.21
-
 Gln-tert-butyl ester pH 8.0, 30°C Homo sapiens
1.33
-
 Gln-tert-butyl ester pH 8.0, 30°C, 0.5 M KCl Carica papaya