Literature summary for 2.3.2.30 extracted from

Gao, J.L.; Weissenmayer, B.; Taylor, A.M.; Thomas-Oates, J.; Lopez-Lara, I.M.; Geiger, O.
Identification of a gene required for the formation of lyso-ornithine lipid, an intermediate in the biosynthesis of ornithine-containing lipids (2004), Mol. Microbiol., 53, 1757-1770 .

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells and in an olsA-deficient mutant of Sinorhizobium meliloti	Sinorhizobium meliloti

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-ornithine + a (3R)-3-hydroxyacyl-[acyl-carrier protein]	Sinorhizobium meliloti	-	a lyso-ornithine lipid + a holo-[acyl-carrier protein]	-	?

Organism

Organism	UniProt	Comment	Textmining
Sinorhizobium meliloti	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-ornithine + (3R)-3-hydroxyacyl-[palmitoyl-carrier protein]	-	Sinorhizobium meliloti	a lyso-ornithine lipid + holo-[palmitoyl-carrier protein]	-	?
L-ornithine + a (3R)-3-hydroxyacyl-[acyl-carrier protein]	-	Sinorhizobium meliloti	a lyso-ornithine lipid + a holo-[acyl-carrier protein]	-	?

Synonyms

Synonyms	Comment	Organism
L-ornithine Nalpha-acyltransferase	-	Sinorhizobium meliloti
olsB	-	Sinorhizobium meliloti

General Information

General Information	Comment	Organism
metabolism	the enzyme is is required for the first step of ornithine-containing lipid biosynthesis. Enzyme overexpression in Escherichia coli is sufficient to cause the in vivo formation of lyso-ornithine lipid in this organism and is the cause for a (3R)-3-hydroxyacyl-[acyl-carrier protein]-dependent acyltransferase activity forming lyso-ornithine lipid from ornithine	Sinorhizobium meliloti

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Release 2023.1 (January 2023)