Application | Comment | Organism |
---|---|---|
medicine | MprF could be a target for new anti-virulence drugs | Staphylococcus aureus |
Cloned (Comment) | Organism |
---|---|
into the vector pET28 | Staphylococcus aureus |
Protein Variants | Comment | Organism |
---|---|---|
D546A | MprF(-8) mutant, replacement results in slightly reduced production of lysyl-phosphatidylglycerol, same result is obtained when the mutation is introduced into the full-length MprF protein | Staphylococcus aureus |
D731A | MprF(-8) mutant, exchange leads to complete abrogation of lysyl-phosphatidylglycerol production, same result is obtained when the mutation is introduced into the full-length MprF protein | Staphylococcus aureus |
E624A | MprF(-8) mutant, exchange leads to complete abrogation of lysyl-phosphatidylglycerol production, same result is obtained when the mutation is introduced into the full-length MprF protein | Staphylococcus aureus |
E685A | MprF(-8) mutant, replacement results in strongly reduced production of lysyl-phosphatidylglycerol, same result is obtained when the mutation is introduced into the full-length MprF protein | Staphylococcus aureus |
K547A | MprF(-8) mutant, exchange leads to complete abrogation of lysyl-phosphatidylglycerol production, same result is obtained when the mutation is introduced into the full-length MprF protein | Staphylococcus aureus |
K621A | MprF(-8) mutant, exchange leads to complete abrogation of lysyl-phosphatidylglycerol production, same result is obtained when the mutation is introduced into the full-length MprF protein | Staphylococcus aureus |
K806A | MprF(-8) mutant, exchange leads to complete abrogation of lysyl-phosphatidylglycerol production, same result is obtained when the mutation is introduced into the full-length MprF protein | Staphylococcus aureus |
MprF(-10) | mutant, truncated protein consisting of residues 363-840 | Staphylococcus aureus |
MprF(-12) | mutant, truncated protein consisting of residues 437-840 | Staphylococcus aureus |
MprF(-14) | mutant, truncated protein consisting of residues 510-840 | Staphylococcus aureus |
MprF(-2) | mutant, truncated protein consisting of residues 84-840 | Staphylococcus aureus |
MprF(-4) | mutant, truncated protein consisting of residues 157-840 | Staphylococcus aureus |
MprF(-6) | mutant, truncated protein consisting of residues 219-840 | Staphylococcus aureus |
MprF(-8) | mutant, truncated protein consisting of residues 274-840 | Staphylococcus aureus |
MprF(-C) | mutant, truncated protein consisting of residues 1-586 | Staphylococcus aureus |
R734A | MprF(-8) mutant, exchange leads to complete abrogation of lysyl-phosphatidylglycerol production, same result is obtained when the mutation is introduced into the full-length MprF protein | Staphylococcus aureus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Staphylococcus aureus | 16020 | - |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
39000 | - |
theoretical, MprF(-14) mutant, truncated protein consisting of residues 510-840 | Staphylococcus aureus |
48000 | - |
theoretical, MprF(-12) mutant, truncated protein consisting of residues 437-840 | Staphylococcus aureus |
56000 | - |
theoretical, MprF(-10) mutant, truncated protein consisting of residues 363-840 | Staphylococcus aureus |
67000 | - |
theoretical, MprF(-8) mutant, truncated protein consisting of residues 274-840 | Staphylococcus aureus |
67000 | - |
theoretical, MprF(-C) mutant, truncated protein consisting of residues 1-586 | Staphylococcus aureus |
75000 | - |
theoretical, MprF(-6) mutant, truncated protein consisting of residues 219-840 | Staphylococcus aureus |
80000 | - |
theoretical, MprF(-4) mutant, truncated protein consisting of residues 157-840 | Staphylococcus aureus |
88000 | - |
theoretical, MprF(-2) mutant, truncated protein consisting of residues 84-840 | Staphylococcus aureus |
97000 | - |
theoretical, MprF wild-type | Staphylococcus aureus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lysyl-tRNALys + phosphatidylglycerol | Staphylococcus aureus | - |
tRNALys + 3-phosphatidyl-1'-(3'-O-L-lysyl)glycerol | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Staphylococcus aureus | Q2G2M2 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-lysyl-tRNALys + phosphatidylglycerol | - |
Staphylococcus aureus | tRNALys + 3-phosphatidyl-1'-(3'-O-L-lysyl)glycerol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lysyltransferase | - |
Staphylococcus aureus |
MprF protein | - |
Staphylococcus aureus |
multiple peptide resistance factor protein | - |
Staphylococcus aureus |