Organism | UniProt | Comment | Textmining |
---|---|---|---|
Caenorhabditis elegans | Q09349 | isoform Ufd-2 | - |
Synonyms | Comment | Organism |
---|---|---|
UFD-2 | - |
Caenorhabditis elegans |
General Information | Comment | Organism |
---|---|---|
physiological function | UFD-2 is a mediator of DNA-damage-induced apoptosis. After initiation of homologous recombination by RAD-51, UFD-2 forms foci that contain substrate-processivity factors including the ubiquitin-selective segregase CDC-48 (p97), the deubiquitination enzyme ATX-3 (Ataxin-3) and the proteasome. In the absence of UFD-2, RAD-51 foci persist, and DNA damage-induced apoptosis is prevented. UFD-2 foci are retained until recombination intermediates are removed by the Holliday-junction-processing enzymes GEN-1, MUS-81 or XPF-1. Formation of UFD-2 foci also requires proapoptotic CEP-1 (p53) signaling | Caenorhabditis elegans |