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Literature summary for 2.3.2.27 extracted from

  • Ham, S.J.; Lee, S.Y.; Song, S.; Chung, J.R.; Choi, S.; Chung, J.
    Interaction between RING1 (R1) and the ubiquitin-like (UBL) domains is critical for the regulation of parkin activity (2016), J. Biol. Chem., 291, 1803-1816.
    View publication on PubMed
Search for more literature for 2.3.2.27

Activating Compound

Activating Compound Comment Organism Structure
PINK1 Parkin activation as an E3 ubiquitin ligase is regulated by PTEN-induced putative kinase 1 Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expressed in HEK-293T and HeLa cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
A46P the mutant shows barely detectable autoubiquitination activity compared to the wild type Homo sapiens
C431S the mutant shows barely detectable autoubiquitination activity compared to the wild type Homo sapiens
K27N the mutant shows barely detectable autoubiquitination activity compared to the wild type Homo sapiens
K48A the mutant has higher autoubiquitination activity than the wild type Homo sapiens
R33Q the mutant shows barely detectable autoubiquitination activity compared to the wild type Homo sapiens
R42P the mutant has higher autoubiquitination activity than the wild type Homo sapiens
T240R the mutant shows barely detectable autoubiquitination activity compared to the wild type Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens Parkin E3 ligase has autoubiquitination activity ?
-
 ?
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine Homo sapiens
-
 [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Parkin E3 ligase has autoubiquitination activity Homo sapiens ?
-
 ?
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine
-
 Homo sapiens [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine
-
 ?

Synonyms

Synonyms Comment Organism
E3 ubiquitin ligase
-
 Homo sapiens
Parkin
-
 Homo sapiens