Literature summary for 2.3.2.27 extracted from

Ho, Y.K.; Zhi, H.; Bowlin, T.; Dorjbal, B.; Philip, S.; Zahoor, M.A.; Shih, H.M.; Semmes, O.J.; Schaefer, B.; Glover, J.N.; Giam, C.Z.
HTLV-1 tax stimulates ubiquitin E3 ligase, ring finger protein 8, to assemble lysine 63-linked polyubiquitin chains for TAK1 and IKK activation (2015), PLoS Pathog., 11, e1005102.

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Application

Application	Comment	Organism
medicine	human T lymphotropic virus type 1 trans-activator/oncoprotein, Tax, stimulates ring finger protein RNF8, and E2 conjugating enzymes, Ubc13:Uev1A and Ubc13:Uev2, for TGFbeta-activated kinase TAK1 and i-kappaB kinase IKK activation. In vitro, the combination of Tax and RNF8 greatly stimulates TAK1, IKK, I-kappaBalpha and JNK phosphorylation. In vivo, RNF8 over-expression augments while RNF8 ablation drastically reduces canonical NF-kappaB activation by Tax. Activation of the non-canonical NF-kappaB pathway by Tax, however, is unaffected by the loss of RNF8. Tax greatly stimulates RNF8 and Ubc13:Uev1A/Uev2 to assemble long K63-polyubiquitin chains. Co-transfection of Tax with increasing amounts of RNF8 greatly induces K63-polyubiquitin assembly in a dose-dependent manner	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-(ubiquitin)n-[Ubc13]-L-cysteine + [ubiquitin]-L-lysine	-	Homo sapiens	[Ubc13]-L-cysteine + N6-(ubiquitin)n-[ubiquitin]-L-lysine	human T lymphotropic virus type 1 trans-activator/oncoprotein Tax greatly stimulates RNF8 and Ubc13:Uev1A/Uev2 to assemble long K63-polyubiquitin chains	?

Synonyms

Synonyms	Comment	Organism
RNF8	-	Homo sapiens

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Release 2023.1 (January 2023)