Literature summary for 2.3.2.27 extracted from

Lim, S.D.; Hwang, J.G.; Han, A.R.; Park, Y.C.; Lee, C.; Ok, Y.S.; Jang, C.S.
Positive regulation of rice RING E3 ligase OsHIR1 in arsenic and cadmium uptakes (2014), Plant Mol. Biol., 85, 365-379.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
nucleus	-	Oryza sativa	5634	-
plasma membrane	-	Oryza sativa	5886	-

Organism

Organism	UniProt	Comment	Textmining
Oryza sativa	Q01I44	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [TIP4.1]-L-lysine	TIP4 i.e. tonoplast intrinsic protein 4	Oryza sativa	[E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[TIP4.1]-L-lysine	HIR1 strongly degrads the protein level of TIP4.1 via the ubiquitin 26S proteasome system	?

Synonyms

Synonyms	Comment	Organism
HIR1	-	Oryza sativa

General Information

General Information	Comment	Organism
physiological function	heterogeneous overexpression of HIR1 in Arabidopsis thaliana leads to As- and Cd-insensitive phenotypes and results in decreased As and Cd accumulation in the shoots and roots	Oryza sativa

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Release 2023.1 (January 2023)