Cloned (Comment) | Organism |
---|---|
expression in Escherichia coli | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | a truncation mutant spanning residues 1-360 and containing the RING finger domain is catalytically active | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q96BH1 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | in combination with E2 ubiquitin-conjugating enzyme UbcM2, only monoubiquitylation of the final substrate occurs. In presence of ubiquitin mutant K48R and UbcM2, enhanced polyubiquitin synthesizing activity is found. Reaction mixtures containing ubiquitin mutant K6R show a mild suppression of UbcM2 activity | Homo sapiens | ? | - |
? | |
S-ubiquitinyl-[UbcM2]-L-cysteine + [acceptor protein]-L-lysine | - |
Homo sapiens | [UbcM2]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
E3 ubiquitin-protein ligase RNF25 | - |
Homo sapiens |