Cloned (Comment) | Organism |
---|---|
expression in HEK-293T cell | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C15A | mutation in the conserved RING-finger domain, loss of autoubiquitination ability | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9C035 | isoform TRIM5 | - |
Posttranslational Modification | Comment | Organism |
---|---|---|
ubiquitination | isoform TRIM5 is monoubiquitinated both by itself and by E3 ubiquitin ligase Ro52, and ubiquitination does not lead to proteasomal degradation. Monoubiquitination may be a signal for TRIM5 to translocate from cytoplasmic bodies to the cytoplasm | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[TRIM5-ubiquitin-carrier protein UbcH5B]-S-ubiquitinyl-L-cysteine + [TRIM5]-L-lysine | TRIM5 functions as a RING-finger-type E3 ubiquitin ligase both in vitro and in vivo and ubiquitinates itself in cooperation with the E2 ubiquitin-conjugating enzyme UbcH5B. TRIM5 is monoubiquitinated, and ubiquitination does not lead to proteasomal degradation. Monoubiquitination may be a signal for TRIM5 to translocate from cytoplasmic bodies to the cytoplasm | Homo sapiens | [TRIM5-ubiquitin-carrier protein UbcH5B]-L-cysteine + [TRIM5]-N6-ubiquitinyl-L-lysine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
TRIM5 | - |
Homo sapiens |
TRIM5alpha | - |
Homo sapiens |
tripartite motif-containing protein 5 | - |
Homo sapiens |