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Literature summary for 2.3.2.26 extracted from

  • Aerne, B.L.; Gailite, I.; Sims, D.; Tapon, N.
    Hippo stabilises its adaptor Salvador by antagonising the HECT ubiquitin ligase Herc4 (2015), PLoS ONE, 10, e0131113.
    View publication on PubMed
Search for more literature for 2.3.2.26

Organism

Organism UniProt Comment Textmining
Drosophila melanogaster
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Drosophila melanogaster S2
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [Sav]-L-lysine Sav i.e. scaffold protein Salvador, believed to promote Hpo/Wts association Drosophila melanogaster [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[Sav]-L-lysine
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 ?
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [Sav]-L-lysine Sav i.e. scaffold protein Salvador, believed to promote Hpo/Wts association Drosophila melanogaster S2 [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[Sav]-L-lysine
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 ?

Synonyms

Synonyms Comment Organism
Herc4
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 Drosophila melanogaster

General Information

General Information Comment Organism
physiological function isoform Herc4 expression promotes scaffold protein Sav ubiquitylation and degradation, while Herc4 depletion stabilises Sav. Sav-binding protein Hpo reduces Sav/Herc4 interaction in a kinase-dependent manner Drosophila melanogaster