Literature summary for 2.3.2.26 extracted from

Edwin, F.; Anderson, K.; Patel, T.B.
HECT domain-containing E3 ubiquitin ligase Nedd4 interacts with and ubiquitinates Sprouty2 (2010), J. Biol. Chem., 285, 255-264.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P46934	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [Spry2]-L-lysine	Spry2 is a regulator of receptor tyrosine kinase signaling in development and disease	Homo sapiens	[E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[Spry2]-L-lysine	isoform Nedd4 polyubiquitinates Spry2 via Lys48 on ubiquitin and decreases its stability. The Spry2/Nedd4 association involves theWW domains of Nedd4 and requires phosphorylation of the Mnk2 kinase sites, Ser112 and Ser121, on Spry2. The phospho-Ser112/121 region on Spry2 that binds WW domains of Nedd4 is a non-canonical WW domain binding region that does not contain Pro residues after phospho-Ser	?

Synonyms

Synonyms	Comment	Organism
Nedd4	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	silencing of endogenous isoform Nedd4 increases the cellular substrate Spry2 content and attenuates fibroblast growth factor-elicited ERK1/2. Mnk2 kinase silencing decreases Spry2-Nedd4 interactions and also augments the ability of Spry2 to inhibit fibroblast growth factor signaling	Homo sapiens

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Release 2023.1 (January 2023)