Cloned (Comment) | Organism |
---|---|
expression in Escherihia coli | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
C2 domain, to 1.96 A resolution. The Smurf1 C2 domain possesses a typical anti-parallel beta-sandwich fold. The Smurf1 C2 domain exerts a key role in localization to the plasma membrane. Lysine residues, Lys-28 and Lys-85, within the C2 domain are important for Smurf1 localization at the plasma membrane, regulation on cell migration, and robust ligase activity toward RhoA, which further supports a Ca2+-independent localization mechanism for Smurf1 | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | autoinhibition mechanism of domains C2-HECT is not observed in isoform Smurf1 | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | the isoform Smurf1 C2 domain exerts a key role in localization to the plasma membrane. Lysine residues, Lys-28 and Lys-85, within the C2 domain are important for Smurf1 localization at the plasma membrane | Homo sapiens | 16020 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9HCE7 | isoform Smurf1 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | C2 domain of isoform Smurf1 functions in substrate selection | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Smurf1 | - |
Homo sapiens |