Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.2.23 extracted from

  • Loh, Y.Y.; Anantharajan, J.; Huang, Q.; Xu, W.; Fulwood, J.; Ng, H.Q.; Ng, E.Y.; Gea, C.Y.; Choong, M.L.; Tan, Q.W.; Koh, X.; Lim, W.H.; Nacro, K.; Cherian, J.; Baburajendran, N.; Ke, Z.; Kang, C.
    Identification of small-molecule binding sites of a ubiquitin-conjugating enzyme-UBE2T through fragment-based screening (2024), Protein Sci., 33, e4904.
    View publication on PubMed
Search for more literature for 2.3.2.23

Crystallization (Commentary)

Crystallization (Comment) Organism
structures in complex with inhibitor fragments, at 1.7 and 1.5 A resolutions, respectively, reveal two unique compound-binding pockets Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
5-([4-[(thiophen-2-yl)acetyl]piperazin-1-yl]methyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Homo sapiens
5-([4-[2-(thiophen-2-yl)ethyl]piperazin-1-yl]methyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Homo sapiens
5-benzylpyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Homo sapiens
5-[(piperidin-1-yl)methyl]pyrazolo[1,5-a]pyrimidin-7(4H)-one
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9NPD8
-
-

Synonyms

Synonyms Comment Organism
HSPC150
-
 Homo sapiens
PIG50
-
 Homo sapiens
UBE2T
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.2882
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-([4-[2-(thiophen-2-yl)ethyl]piperazin-1-yl]methyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
0.3322
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-[(piperidin-1-yl)methyl]pyrazolo[1,5-a]pyrimidin-7(4H)-one
0.4274
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-([4-[(thiophen-2-yl)acetyl]piperazin-1-yl]methyl)pyrazolo[1,5-a]pyrimidin-7(4H)-one
0.6216
-
 pH not specified in the publication, temperature not specified in the publication Homo sapiens 5-benzylpyrazolo[1,5-a]pyrimidin-7(4H)-one