Any feedback?
Literature summary for 2.3.2.23 extracted from
- The ubiquitin-conjugating enzyme UBE2D maintains a youthful proteome and ensures protein quality control during aging by sustaining proteasome activity (2025), PLoS Biol., 23, e3002998.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Drosophila melanogaster | P25867 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| retina | - |
Drosophila melanogaster | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| eff | - |
Drosophila melanogaster |
| effete | - |
Drosophila melanogaster |
| UBE2D | - |
Drosophila melanogaster |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | UBE2D/eff is required for huntingtin-polyQ degradation. In skeletal muscle, eff protein levels decline with aging, and muscle-specific eff knockdown causes an accelerated buildup in insoluble poly-ubiquitinated proteins and shortens lifespan. UBE2D/eff knockdown reduces the proteolytic activity of the proteasome. UBE2D/eff knockdown in young age reproduces part of the proteomic changes that normally occur in old muscles | Drosophila melanogaster |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2026.1 (March 2026)
Legal
Curated at
Member of
![DSMZ Digital Diversity]()
![Global Core Biodata Resource]()
![ELIXIR Core Data Resource]()
![German Network for Bioinformatics Infrastructure]()
