Literature summary for 2.3.2.23 extracted from

Rodriguez Tirado, C.; Wang, C.; Li, X.; Deng, S.; Gonzalez, J.; Johnson, N.A.; Xu, Y.; Metang, L.A.; Sundar Rajan, M.; Yang, Y.; Yin, Y.; Hofstad, M.; Raj, G.V.; Zhang, S.; Lemoff, A.; He, W.; Fan, J.; Wang, Y.; Wang, T.; Mu, P.
UBE2J1 is the E2 ubiquitin-conjugating enzyme regulating androgen receptor degradation and antiandrogen resistance (2024), Oncogene, 43, 265-280.

Search for more literature for 2.3.2.23

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q9Y385	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
prostate gland	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
CGI-76	-	Homo sapiens
HSPC153	-	Homo sapiens
HSPC205	-	Homo sapiens
NCUBE1	-	Homo sapiens
Ube2J1	-	Homo sapiens

General Information

General Information	Comment	Organism
malfunction	isoform UBE2J1 is responsible for androgen receptor ubiquitination and eventual degradation. The absence of UBE2J1, found in 5-15% of prostate cancer patients, results in disrupted androgen receptor ubiquitination and degradation, leading to an accumulation of androgen receptor proteins and promoting resistance to anti-androgen treatments. Reestablishing androgen receptor degradation inhibits the proliferation of antiandrogen-resistant prostate cancer tumors	Homo sapiens
physiological function	isoform UBE2J1 is responsible for androgen receptor ubiquitination and eventual degradation. The absence of UBE2J1 results in disrupted androgen receptor ubiquitination and degradation, leading to an accumulation of androgen receptor proteins	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2026.1 (March 2026)