Any feedback?
Literature summary for 2.3.2.23 extracted from
- Targeting E2 ubiquitin-conjugating enzyme UbcH5c by small molecule inhibitor suppresses pancreatic cancer growth and metastasis (2022), Mol. Cancer, 21, 70.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | UbcH5c is positively correlated with the expression of inhibitor of apoptosis proteins (IAPs) in pancreatic cancer and is overexpressed and associated with a poor prognosis in pancreatic cancer | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2alpha,6alpha-diacetoxy-4beta-hydroxy-11(13)-pseudoguaien-12,8alpha-olide | inhibitor directly binds to UbcH5c protein and inhibits cell viability and colony formation, induces apoptosis, and suppresses migration and invasion of pancreatic cancer cells in vitro. The compound inhibits UbcH5c-mediated IkappaBalpha degradation and NF-kappaB activation. The compound suppresses the tumor growth and metastasis in two orthotopic pancreatic tumor mouse models | Homo sapiens |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P61077 | cf. EC 2.3.2.24 | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UBC5C | - |
Homo sapiens |
| UbcH5C | - |
Homo sapiens |
| UBE2D3 | - |
Homo sapiens |
| ubiquitin-conjugating enzyme E2 D3 | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | UbcH5c is overexpressed and associated with a poor prognosis in pancreatic cancer | up |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2026.1 (March 2026)
Legal
Curated at
Member of
![DSMZ Digital Diversity]()
![Global Core Biodata Resource]()
![ELIXIR Core Data Resource]()
![German Network for Bioinformatics Infrastructure]()
