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Literature summary for 2.3.2.23 extracted from

  • Kuang, W.; Zhuge, R.; Song, P.; Yi, L.; Zhang, S.; Zhang, Y.; Wong, Y.K.; Chen, R.; Zhang, J.; Wang, Y.; Liu, D.; Gong, Z.; Wang, P.; Ouyang, X.; Wang, J.
    Eupalinolide B inhibits periodontitis development by targeting ubiquitin conjugating enzyme UBE2D3 (2025), MedComm. (2020), 6, e70034.
    View publication on PubMed
Search for more literature for 2.3.2.23

Inhibitors

Inhibitors Comment Organism Structure
eupalinolide B Kd value 0.00925 mM. UBE2D3 is modified by EB in residue Cys85, the presence of eupalinolide B enhances the thermal stabilization of UBE2D3. Eupanolide B effectively inhibits the activity of UBE2D3 and prevents the degradation of IkappaBalpha and the activation of NF-kappaB Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytoplasm
-
 Mus musculus 5737
-

Organism

Organism UniProt Comment Textmining
Mus musculus P61079 cf. EC 2.3.2.24
-

Source Tissue

Source Tissue Comment Organism Textmining
RAW-264.7 cell
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
UBE2D3
-
 Mus musculus

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
additional information
-
 presence of eupalinolide B enhances the thermal stability of UBE2D3 Mus musculus

General Information

General Information Comment Organism
physiological function silencing of Ube2d3 impairs the eupalinolide B-mediated anti-inflammatory protective effect in activated RAW-264.7 cells Mus musculus