Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.2.23 extracted from

  • Wang, P.; Li, Y.; Ma, Y.; Zhang, X.; Li, Z.; Yu, W.; Zhu, M.; Wang, J.; Xu, Y.; Xu, A.
    Comprehensive investigation into the role of ubiquitin-conjugating enzyme E2S in melanoma development (2021), J. Invest. Dermatol., 141, 374-384.
    View publication on PubMed
Search for more literature for 2.3.2.23

Application

Application Comment Organism
medicine UBE2S is overexpressed in malignant melanoma cells and tissues, and UBE2S expression is significantly different between tumor node metastasis staging T4 and T1/T2/T3. UBE2S short hairpin RNA treatment may cause cell cycle arrest in G1/S phase, inhibit proliferation, induce apoptosis, and suppress tumor growth Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16763
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-375 cell
-
 Homo sapiens
-
MUM-2B cell
-
 Homo sapiens
-
SK-MEL-28 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
UBE2S
-
 Homo sapiens

Expression

Organism Comment Expression
Homo sapiens UBE2S is overexpressed in malignant melanoma cells and tissues, and UBE2S expression is significantly different between tumor node metastasis staging T4 and T1/T2/T3 up

General Information

General Information Comment Organism
physiological function in UBE2S short hairpin RNA (shUBE2S) treated melanoma cells, proliferation of melanoma cells is inhibited, apoptosis is increased, and cell cycle is arrested in G1/S. 247 genes and 265 genes are upregulated and downregulated, respectively. These genes are mainly involved in immune reactions, apoptosis, DNA damage repair, and cell movement. Expression of epithelial to mesenchymal transitionerelated proteins is significantly suppressed, and tumor growth is also suppressed in shUBE2S BALB/C nude mice Homo sapiens