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Literature summary for 2.3.2.23 extracted from
- The E2 ubiquitin-conjugating enzymes UBE2D1 and UBE2D2 regulate VEGFR2 dynamics and endothelial function (2023), J. Cell Sci., 136, jcs260657.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P51668 | cf. EC 2.3.2.24 | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| PUBC1 | - |
Homo sapiens |
| Ubc4 | - |
Homo sapiens |
| UBC5B | - |
Homo sapiens |
| UBCH4 | - |
Homo sapiens |
| UbcH5B | - |
Homo sapiens |
| UBE2D2 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | depletion of either UBE2D1 or UBE2D2 in endothelial cells causes a rise in steady-state VEGFR2 levels, whioch impacts on VEGF-A-stimulated signalling, with increased activation of canonical MAPK, phospholipase Cgamma1 and Akt pathways. VEGFR2 recycling to the plasma membrane is increased upon reduction in UBE2D levels. Depletion of either UBE2D1 or UBE2D2 stimulates endothelial tubulogenesis | Homo sapiens |
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