Any feedback?
Literature summary for 2.3.2.23 extracted from
- Ubiquitin-conjugating enzyme E2S decreases the sensitivity of glioblastoma cells to temozolomide by upregulating PGAM1 via the interaction with OTUB2 (2025), Int. J. Biol. Macromol., 302, 140583.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | in glioblastoma cells, UBE2S interacts with phosphoglycerate mutase PGAM1 and otubain-2 to inhibit PGAM1 degradation via K48-linked deubiquitylation. This increases PGAM1 protein levels, promoting DNA repair and reducing apoptosis, thereby decreasing the sensitivity of glioblastoma cells to temozolomide | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q16763 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| E2EPF | - |
Homo sapiens |
| OK/SW-cl.73 | - |
Homo sapiens |
| UBE2S | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | expression is increased in glioblastoma cells | up |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2026.1 (March 2026)
Legal
Curated at
Member of
![DSMZ Digital Diversity]()
![Global Core Biodata Resource]()
![ELIXIR Core Data Resource]()
![German Network for Bioinformatics Infrastructure]()
