Literature summary for 2.3.2.23 extracted from

Jin, B.; Li, B.; Qu, J.; Sun, Y.; Wang, M.; Yang, C.; Fan, Y.; Wang, Y.; Xu, P.; Sun, H.; Jiang, B.; Zhao, B.
Recruitment of ubiquitin E2 enzymes is determined jointly by the U-box domains and substrates of E3 ligases (2024), FEBS Lett., 598, 702-715.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HEK-293T cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
additional information	ubiquitination by E3 ligases CHIP and E4B is mediated via different E2 enzymes. The U-box domains of E3s determine the E2 recruitment, while the substrate determines the E2 selectivity	Homo sapiens

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Release 2026.1 (March 2026)