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Literature summary for 2.3.2.23 extracted from
- Ubiquitin conjugating enzyme E2°C (UBE2C) may play a dual role involved in the progression of thyroid carcinoma (2022), Cell Death Discov., 8, 130.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | high expression of UBE2C independently predicts a shorter disease-free survival time of thyroid carcinoma patients. UBE2C also presents a better prognostic performance on the survival probability of patients | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O00762 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UBE2C | - |
Homo sapiens |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Homo sapiens | UBE2C is overexpressed in thyroid carcinoma and it correlates with cancer cell growth | additional information |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | after UBE2C knockdown, the proliferation of thyroid carcinoma cells is inhibited and apoptosis is increased. The migration and invasion of of thyroid carcinoma cells is enhanced upon UBE2C knockdown , and the expressions of migration-related proteins is upregulated. UBE2C knockdown increases the resistance of UBE2C knockdown cells to sorafenib | Homo sapiens |
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