Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.2.23 extracted from

  • Chakrabarti, K.S.; Li, J.; Das, R.; Byrd, R.A.
    Conformational dynamics and allostery in E2 E3 interactions drive ubiquitination gp78 and Ube2g2 (2017), Structure, 25, 794-805.
    View publication on PubMed
Search for more literature for 2.3.2.23

Organism

Organism UniProt Comment Textmining
Homo sapiens P60604
-
-

Synonyms

Synonyms Comment Organism
UBE2G2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function study on energy landscapes during the initial phases of the ubiquitination reaction, on Ube2g2 in the free form and in complex with E3 enzyme gp78 domains RING and G2BR. Ube2g2 goes through a sequence of allosteric binding to gp78, transfer of Ub, and release from gp78 during the ubiquitination reaction. Ube2g2 dynamics is significantly modulated along this pathway, and the population distribution in the dynamic energy landscape drives the sequence of allosteric binding, catalysis and release Homo sapiens