Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P62253 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | human liver endoplasmic reticulum-anchored cytochrome P450 enzyme CYP3A4 is degraded via ubiquitylation by E2 ubiquitin-conjugating enzyme UBC7/E3 ubiquitin-ligase gp78, reaction of EC 2.3.2.27. CYP3A4 Asp/Glu/Ser(P)/Thr(P) surface clusters are important for its intermolecular electrostatic interactions with each of these E2-E3 subcomponents. By imparting additional negative charge to these Asp/Glu clusters, such Ser/Thr phosphorylation would generate P450 phosphodegrons for molecular recognition by the E2-E3 complexes, thereby controlling the timing of CYP3A4 ubiquitination and endoplasmic reticulum-associated degradation | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UBC7 | - |
Homo sapiens |
ubiquitin-conjugating enzyme E2 G1 | - |
Homo sapiens |