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Literature summary for 2.3.2.23 extracted from

  • Aichem, A.; Catone, N.; Groettrup, M.
    Investigations into the auto-FAT10ylation of the bispecific E2 conjugating enzyme UBA6-specific E2 enzyme 1 (2014), FEBS J., 281, 1848-1859.
    View publication on PubMed
Search for more literature for 2.3.2.23

Protein Variants

Protein Variants Comment Organism
K323R mutation in site of auto-FAT10ylation. Mutation does not abolish auto-FAT10ylation of USE1, but every other lysine can instead be modified with FAT10 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9H832
-
-

Synonyms

Synonyms Comment Organism
UBA6-specific E2 enzyme 1
-
 Homo sapiens
ubiquitin-conjugating enzyme E2 Z
-
 Homo sapiens
USE1
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 Homo sapiens

General Information

General Information Comment Organism
physiological function USE1 modifies itself with HLA-F adjacent transcript 10, i.e. FAT10, in cis, mainly at Lys323. Mutation of Lys323 to an arginine does not abolish auto-FAT10ylation of USE1, but every other lysine can instead be modified with FAT10. FAT10ylation of USE1 accelerates its proteasomal degradation. The USE1Β–FAT10 conjugate continues to be an active E2 enzyme Homo sapiens