Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.2.23 extracted from

  • Plafker, K.S.; Nguyen, L.; Barneche, M.; Mirza, S.; Crawford, D.; Plafker, S.M.
    The ubiquitin-conjugating enzyme UbcM2 can regulate the stability and activity of the antioxidant transcription factor Nrf2 (2010), J. Biol. Chem., 285, 23064-23074.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.2.23

Protein Variants

Protein Variants Comment Organism
C136F mutation results in constitutive binding of UbcM2 to transcription factor Nrf2 and an increased half-life of the transcription factor in vivo Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293T cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
UbcM2
-
 Homo sapiens

General Information

General Information Comment Organism
physiological function ubiquitin-conjugating enzyme UbcM2 is a regulator of transcription factor nuclear factor E2-related factor Nrf2. Nrf2 induces the expression of antioxidant gene products that neutralize reactive oxygen species and restore redox homeostasis Recombinant Nrf2 and UbcM2 form a complex upon alkylation of a non-catalytic cysteine in UbcM2, Cys-136. UbcM2 and Nrf2 form a nuclear complex utilizing the DNA binding Neh1 domain of Nrf2. UbcM2 can enhance the transcriptional activity of endogenous Nrf2 and Cys-136 and the active-site cysteine, Cys-145, jointly contribute to this regulation Homo sapiens