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Literature summary for 2.3.2.23 extracted from
- The ubiquitin-conjugating enzyme UbcM2 can regulate the stability and activity of the antioxidant transcription factor Nrf2 (2010), J. Biol. Chem., 285, 23064-23074.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C136F | mutation results in constitutive binding of UbcM2 to transcription factor Nrf2 and an increased half-life of the transcription factor in vivo | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HEK-293T cell | - |
Homo sapiens | - |
| HeLa cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UbcM2 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | ubiquitin-conjugating enzyme UbcM2 is a regulator of transcription factor nuclear factor E2-related factor Nrf2. Nrf2 induces the expression of antioxidant gene products that neutralize reactive oxygen species and restore redox homeostasis Recombinant Nrf2 and UbcM2 form a complex upon alkylation of a non-catalytic cysteine in UbcM2, Cys-136. UbcM2 and Nrf2 form a nuclear complex utilizing the DNA binding Neh1 domain of Nrf2. UbcM2 can enhance the transcriptional activity of endogenous Nrf2 and Cys-136 and the active-site cysteine, Cys-145, jointly contribute to this regulation | Homo sapiens |
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