Literature summary for 2.3.2.23 extracted from

Pelzer, C.; Kassner, I.; Matentzoglu, K.; Singh, R.K.; Wollscheid, H.P.; Scheffner, M.; Schmidtke, G.; Groettrup, M.
UBE1L2, a novel E1 enzyme specific for ubiquitin (2007), J. Biol. Chem., 282, 23010-23014.

Search for more literature for 2.3.2.23

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P62837	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
SW-60 cell	colon carcinoma cell	Homo sapiens	-
testis	most abundant expression	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
[ubiquitin-activating protein Uba6]-S-ubiquitinyl-L-cysteine + [ubiquitin carrier protein UbcH5B]-L-cysteine	-	Homo sapiens	[ubiquitin-activating protein Uba]-L-cysteine + [ubiquitin carrier protein UbcH5B]-S-ubiquitinyl-L-cysteine	recombinant E1 enzyme Uba6 can activate ubiquitin and transfer it onto the ubiquitin-conjugating enzyme UbcH5B. Ubiquitin activated by Uba6 can be used for ubiquitylation of p53 and supports the autoubiquitylation of the E3 ubiquitin ligases HectH9 and E6-AP	?

Synonyms

Synonyms	Comment	Organism
Ubc4	-	Homo sapiens
UbcH5B	-	Homo sapiens

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Release 2026.1 (March 2026)