Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
K-562 cell | - |
Homo sapiens | - |
MEG-01 cell | - |
Homo sapiens | - |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | tumor necrosis factor TNFalpha induces GGT promoter transactivation, mRNA and protein synthesis, as well as enzymatic activity. Remicade, a clinically used anti-TNFalpha antibody, small interfering RNA against p50 and p65 nuclear factor NF-kB isoforms, curcumin, a well characterized natural NF-kB inhibitor, as well as a dominant negative inhibitor IkBa, prevent GGT activation at various levels. Over-expression of receptor of TNFalpha-1, TNFR-associated factor-2 TRAF2, TNFR-1 associated death domain TRADD, dominant negative IkBa or NF-kB p65 further confirm GGT promoter activation via NF-kB.Mutation of the NF-kB site located at 110 additionally inhibits TNFalpha-induced promoter induction | up |