Literature summary for 2.3.2.15 extracted from

Meyer, C.L.; Peisker, D.; Courbot, M.; Craciun, A.R.; Cazale, A.C.; Desgain, D.; Schat, H.; Clemens, S.; Verbruggen, N.
Isolation and characterization of Arabidopsis halleri and Thlaspi caerulescens phytochelatin synthases (2011), Planta, 234, 83-95.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Saccharomyces cerevisiae strain BY4741	Arabidopsis halleri
expressed in Saccharomyces cerevisiae strain BY4741	Noccaea caerulescens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Cd2+	Cd2+ activates the enzyme. Extremely efficient alternative cadmium sequestration pathways in leaves of cadmium hyperaccumulators prevent activation of phytochelatin synthase by cadmium ions	Arabidopsis halleri
Cd2+	Cd2+ activates the enzyme. Extremely efficient alternative cadmium sequestration pathways in leaves of cadmium hyperaccumulators prevent activation of phytochelatin synthase by cadmium ions	Noccaea caerulescens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
54000	-	x * 54000, calculated from amino acid sequence	Arabidopsis halleri
54000	-	x * 54000, calculated from amino acid sequence	Noccaea caerulescens

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis halleri	F1KLT6	isoform PCS2	-
Arabidopsis halleri	Q56VL5	isoform PCS1	-
Noccaea caerulescens	B3FMV8	isoform PCS2; formerly Thlaspi caerulescens	-
Noccaea caerulescens	Q698X7	isoform PCS1; formerly Thlaspi caerulescens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
glutathione + [Glu(-Cys)]n-Gly	-	Arabidopsis halleri	Gly + [Glu(-Cys)]n+1-Gly	-	?
glutathione + [Glu(-Cys)]n-Gly	-	Noccaea caerulescens	Gly + [Glu(-Cys)]n+1-Gly	-	?

Subunits

Subunits	Comment	Organism
?	x * 54000, calculated from amino acid sequence	Arabidopsis halleri
?	x * 54000, calculated from amino acid sequence	Noccaea caerulescens

Synonyms

Synonyms	Comment	Organism
PCS1	isoform	Noccaea caerulescens
PCS1	isoform	Arabidopsis halleri
PCS2	isoform	Arabidopsis halleri
PCS2	isoform	Noccaea caerulescens
phytochelatin synthase	-	Arabidopsis halleri
phytochelatin synthase	-	Noccaea caerulescens

General Information

General Information	Comment	Organism
physiological function	the enzyme is involved in cellular cadmium tolerance	Arabidopsis halleri
physiological function	the enzyme is involved in cellular cadmium tolerance	Noccaea caerulescens

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Release 2023.1 (January 2023)