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Literature summary for 2.3.2.13 extracted from
- Analysis on transglutaminase 1 and its substrates using specific substrate peptide in cultured keratinocytes (2016), Biochem. Biophys. Res. Commun., 478, 343-348 .
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| plasma membrane | isozyme TG1 is mainly attached to the plasma membrane | Homo sapiens | 5886 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | required for activity | Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Alfa-crystallin B glutamine + pentylamine | Homo sapiens | - |
Alfa-crystallin B N5-pentylglutamine + NH3 | - |
? | |
| cornifin-A glutamine + pentylamine | Homo sapiens | cornifin-A is SPR1 | cornifin-A N5-pentylglutamine + NH3 | - |
? | |
| desmoplakin glutamine + pentylamine | Homo sapiens | - |
desmoplakin N5-pentylglutamine + NH3 | - |
? | |
| epiplakin glutamine + pentylamine | Homo sapiens | - |
epiplakin N5-pentylglutamine + NH3 | - |
? | |
| hornein glutamine + pentylamine | Homo sapiens | - |
hornein N5-pentylglutamine + NH3 | - |
? | |
| involucrin glutamine + pentylamine | Homo sapiens | - |
involucrin N5-pentylglutamine + NH3 | - |
? | |
| junction plakoglobin glutamine + pentylamine | Homo sapiens | - |
junction plakoglobin N5-pentylglutamine + NH3 | - |
? | |
| kallikrein-10 glutamine + pentylamine | Homo sapiens | - |
kallikrein-10 N5-pentylglutamine + NH3 | - |
? | |
| additional information | Homo sapiens | several substrate candidates of TG1 that may be essential for cornified envelope formation are identified and characterized | ? | - |
- |
|
| plasminogen activator inhibitor 2 glutamine + pentylamine | Homo sapiens | - |
plasminogen activator inhibitor 2 N5-pentylglutamine + NH3 | - |
? | |
| protein glutamine + alkylamine | Homo sapiens | - |
protein N5-alkylglutamine + NH3 | - |
? | |
| protein S100A10 glutamine + pentylamine | Homo sapiens | - |
protein S100A10 N5-pentylglutamine + NH3 | - |
? | |
| SPR2D glutamine + pentylamine | Homo sapiens | - |
SPR2D N5-pentylglutamine + NH3 | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P22735 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epidermis | - |
Homo sapiens | - |
| keratinocyte | neonate keratinoycte cell culture | Homo sapiens | - |
| skin | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| Alfa-crystallin B glutamine + pentylamine | - |
Homo sapiens | Alfa-crystallin B N5-pentylglutamine + NH3 | - |
? | |
| cornifin-A glutamine + pentylamine | cornifin-A is SPR1 | Homo sapiens | cornifin-A N5-pentylglutamine + NH3 | - |
? | |
| desmoplakin glutamine + pentylamine | - |
Homo sapiens | desmoplakin N5-pentylglutamine + NH3 | - |
? | |
| epiplakin glutamine + pentylamine | - |
Homo sapiens | epiplakin N5-pentylglutamine + NH3 | - |
? | |
| hornein glutamine + pentylamine | - |
Homo sapiens | hornein N5-pentylglutamine + NH3 | - |
? | |
| involucrin glutamine + pentylamine | - |
Homo sapiens | involucrin N5-pentylglutamine + NH3 | - |
? | |
| junction plakoglobin glutamine + pentylamine | - |
Homo sapiens | junction plakoglobin N5-pentylglutamine + NH3 | - |
? | |
| kallikrein-10 glutamine + pentylamine | - |
Homo sapiens | kallikrein-10 N5-pentylglutamine + NH3 | - |
? | |
| additional information | several substrate candidates of TG1 that may be essential for cornified envelope formation are identified and characterized | Homo sapiens | ? | - |
- |
|
| plasminogen activator inhibitor 2 glutamine + pentylamine | - |
Homo sapiens | plasminogen activator inhibitor 2 N5-pentylglutamine + NH3 | - |
? | |
| protein glutamine + alkylamine | - |
Homo sapiens | protein N5-alkylglutamine + NH3 | - |
? | |
| protein S100A10 glutamine + pentylamine | - |
Homo sapiens | protein S100A10 N5-pentylglutamine + NH3 | - |
? | |
| SPR2D glutamine + pentylamine | - |
Homo sapiens | SPR2D N5-pentylglutamine + NH3 | - |
? | |
| YENHKLPSSWPF + alkylamine | N-terminally biotinylated peptide substrate | Homo sapiens | Y-N5-alkylglutaminyl-NHKLPSSWPF + NH3 | - |
? | |
| YEQHKLPSSWPF + pentylamine | N-terminally biotinylated peptide substrate | Homo sapiens | Y-N5-pentylglutaminyl-QHKLPSSWPF + NH3 | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| TGase | - |
Homo sapiens |
| transglutaminase | - |
Homo sapiens |
| transglutaminase 1 | - |
Homo sapiens |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | transglutaminase (TGase) catalyzes protein cross-linking reactions essential for several biological processes. In differentiating keratinocytes, TG1 (keratinocyte-type) is crucial for the cross-linking of substrate proteins required for the complete formation of the cornified envelope, a proteinaceous supermolecule located in the outermost layer of the epidermis | Homo sapiens |
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