Literature summary for 2.3.2.13 extracted from

Yu, J.; Pian, Y.; Ge, J.; Guo, J.; Zheng, Y.; Jiang, H.; Hao, H.; Yuan, Y.; Jiang, Y.; Yang, M.
Functional and structural characterization of the antiphagocytic properties of a novel transglutaminase from Streptococcus suis (2015), J. Biol. Chem., 290, 19081-19092.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Streptococcus suis

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapor diffusion method, using 0.2 M sodium chloride, 0.1 M HEPES, pH 7.2, 20% (w/v) polyethylene glycol 4000	Streptococcus suis

Protein Variants

Protein Variants	Comment	Organism
C302A	the mutant shows dramatically decreasing activity compared to the wild type enzyme	Streptococcus suis
D348A	the mutant shows dramatically decreasing activity compared to the wild type enzyme	Streptococcus suis
H333A	the mutant shows dramatically decreasing activity compared to the wild type enzyme	Streptococcus suis

Organism

Organism	UniProt	Comment	Textmining
Streptococcus suis	A5JSJ3	serotype 2	-

Purification (Commentary)

Purification (Comment)	Organism
glutathione affinity column chromatography	Streptococcus suis

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-carbobenzoxy-Gln-Gly + cadaverine	-	Streptococcus suis	?	-	?

Subunits

Subunits	Comment	Organism
homodimer	-	Streptococcus suis

Synonyms

Synonyms	Comment	Organism
TGase	-	Streptococcus suis
transglutaminase	-	Streptococcus suis

General Information

General Information	Comment	Organism
malfunction	enzyme inactivation significantly reduces the virulence of Streptococcus suis serotype 2 in a pig infection model and impairs its antiphagocytosis in human blood	Streptococcus suis
physiological function	the enzyme is a virulence factor in Streptococcus suis serotype 2 with antiphagocytic activity	Streptococcus suis

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Release 2023.1 (January 2023)