Application | Comment | Organism |
---|---|---|
medicine | colocalization of isoform TG2 and fibronectin in glioblastoma extracellular matrix and secretion of high levels of enzyme and fibronectin by small clusters of invading human glioblastoma cells present in non-neoplastic brain. Downregulation of enzyme by RNAi in U87MG glioblastoma cells demonstrates decreases assembly of fibronectin in the extracellular matrix. KCC009 inhibits the enzyme and subsequently blocks fibronectin assembly in the extracellular matrix of glioblastoma cells | Homo sapiens |
medicine | KCC009 treatment in mice harboring orthotopic glioblastomas sensitizes the tumors to N,NĀ-bis(2-chloroethyl)-N-nitrosourea chemotherapy | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | downregulation of enzyme by RNAi in U87MG glioblastoma cells demonstrates decreased assembly of fibronectin in the extracellular matrix | Mus musculus |
additional information | downregulation of enzyme by RNAi in U87MG glioblastoma cells demonstrates decreases assembly of fibronectin in the extracellular matrix | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
KCC009 | inhibition of enzyme and subsequent block of fibronectin assembly in the extracellular matrix of glioblastoma cells | Homo sapiens | |
KCC009 | inhibition of enzyme and subsequent block of fibronectin assembly in the extracellular matrix of glioblastoma cells in vitro and in vivo. KCC009 treatment in mice harboring orthotopic glioblastomas sensitizes the tumors to N,NĀ-bis(2-chloroethyl)-N-nitrosourea chemotherapy | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Mus musculus | - |
- |
extracellular | colocalization of isoform TG2 and fibronectin in glioblastoma extracellular matrix and secretion of high levels of enzyme and fibronectin by small clusters of invading human glioblastoma cells present in non-neoplastic brain | Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
anaplastic astrocytoma cell | - |
Mus musculus | - |
anaplastic astrocytoma cell | - |
Homo sapiens | - |
brain | - |
Mus musculus | - |
brain | - |
Homo sapiens | - |
glioblastoma cell | isoform TG2 activity is elevated in glioblastomas compared with non-neoplastic brain | Mus musculus | - |
glioblastoma cell | isoform TG2 activity is eleveated in glioblastomas compared with non-neoplastic brain | Homo sapiens | - |