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Literature summary for 2.3.2.13 extracted from

  • Yuan, L.; Siegel, M.; Choi, K.; Khosla, C.; Miller, C.R.; Jackson, E.N.; Piwnica-Worms, D.; Rich, K.M.
    Transglutaminase 2 inhibitor, KCC009, disrupts fibronectin assembly in the extracellular matrix and sensitizes orthotopic glioblastomas to chemotherapy (2007), Oncogene, 26, 2563-2573.
    View publication on PubMed

Application

Application Comment Organism
medicine colocalization of isoform TG2 and fibronectin in glioblastoma extracellular matrix and secretion of high levels of enzyme and fibronectin by small clusters of invading human glioblastoma cells present in non-neoplastic brain. Downregulation of enzyme by RNAi in U87MG glioblastoma cells demonstrates decreases assembly of fibronectin in the extracellular matrix. KCC009 inhibits the enzyme and subsequently blocks fibronectin assembly in the extracellular matrix of glioblastoma cells Homo sapiens
medicine KCC009 treatment in mice harboring orthotopic glioblastomas sensitizes the tumors to N,NĀ’-bis(2-chloroethyl)-N-nitrosourea chemotherapy Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information downregulation of enzyme by RNAi in U87MG glioblastoma cells demonstrates decreased assembly of fibronectin in the extracellular matrix Mus musculus
additional information downregulation of enzyme by RNAi in U87MG glioblastoma cells demonstrates decreases assembly of fibronectin in the extracellular matrix Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
KCC009 inhibition of enzyme and subsequent block of fibronectin assembly in the extracellular matrix of glioblastoma cells Homo sapiens
KCC009 inhibition of enzyme and subsequent block of fibronectin assembly in the extracellular matrix of glioblastoma cells in vitro and in vivo. KCC009 treatment in mice harboring orthotopic glioblastomas sensitizes the tumors to N,NĀ’-bis(2-chloroethyl)-N-nitrosourea chemotherapy Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
Mus musculus
-
-
extracellular colocalization of isoform TG2 and fibronectin in glioblastoma extracellular matrix and secretion of high levels of enzyme and fibronectin by small clusters of invading human glioblastoma cells present in non-neoplastic brain Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
anaplastic astrocytoma cell
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Mus musculus
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anaplastic astrocytoma cell
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Homo sapiens
-
brain
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Mus musculus
-
brain
-
Homo sapiens
-
glioblastoma cell isoform TG2 activity is elevated in glioblastomas compared with non-neoplastic brain Mus musculus
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glioblastoma cell isoform TG2 activity is eleveated in glioblastomas compared with non-neoplastic brain Homo sapiens
-