Literature summary for 2.3.2.13 extracted from

Ahvazi, B.; Kim, H.C.; Kee, S.H.; Nemes, Z.; Steinert, P.M.
Three-dimensional structure of the human transglutaminase 3 enzyme: binding of calcium ions changes structure for activation (2002), EMBO J., 21, 2055-2067.

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Cloned(Commentary)

Cloned (Comment)	Organism
expression of transglutaminase 3 in Sf9 cells	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging drop vapour diffusion, 15 mg/ml transglutaminase 3, 0.1 mM beta-octylglucoside in 0.1 ml of enzyme in 20 mM Tris-HCl, pH 8.0, 1 mM EDTA, 125 mM NaCl and 3 mM CaCl2, well solution containing 4-12% polyethylene glycol 6K, 100 mM bicine, pH 9.0, and 1% dioxane at 21°C, X-ray structure of zymogen and activated transglutaminase 3 at 2.2 and 2.1 A resolution	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Ca2+	transglutaminase 3 binds 3 Ca2+ ions, Er3+, Sm3+, Tb3+ and Lu3+ can substitute for Ca2+ to retain activity	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	Q08188	-	-

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Release 2023.1 (January 2023)