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Literature summary for 2.3.2.13 extracted from
- Transglutaminases: multifunctional cross-linking enzymes that stabilize tissues (1991), FASEB J., 5, 3071-3077.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| thrombin | - |
Cavia porcellus | |
| thrombin | - |
Mus musculus | |
| thrombin | - |
Homo sapiens | |
| thrombin | - |
Rattus norvegicus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| cloning of placenta FXIIIa-gene cDNA | Homo sapiens |
| factor XIII, transglutaminase C and transglutaminase K | Homo sapiens |
| liver transglutaminase C | Cavia porcellus |
| transglutaminase C from macrophage | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| GTP | inhibition of tissue transglutaminase | Cavia porcellus |  |
| GTP | inhibition of tissue transglutaminase | Homo sapiens | |
| GTP | inhibition of tissue transglutaminase | Mus musculus | |
| GTP | inhibition of tissue transglutaminase | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | tissue transglutaminase, factor XIIIa | Cavia porcellus | 5737 | - |
| cytoplasm | tissue transglutaminase, factor XIIIa | Mus musculus | 5737 | - |
| cytoplasm | tissue transglutaminase, factor XIIIa | Homo sapiens | 5737 | - |
| cytoplasm | tissue transglutaminase, factor XIIIa | Rattus norvegicus | 5737 | - |
| membrane | - |
Rattus norvegicus | 16020 | - |
| membrane | keratocytes | Homo sapiens | 16020 | - |
| particle-bound | - |
Cavia porcellus | - |
- |
| particle-bound | - |
Homo sapiens | - |
- |
| particle-bound | on the surface of monocytes and tissue macrophages | Mus musculus | - |
- |
| particle-bound | tissue transglutaminase of rat hepatocytes | Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | requirement | Cavia porcellus | |
| Ca2+ | requirement | Mus musculus | |
| Ca2+ | requirement | Homo sapiens | |
| Ca2+ | requirement | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 80000 | - |
alpha2beta2, 2 * 83005 + 2 * 80000, plasma factor XIII, deduced from amino acid sequence | Homo sapiens |
| 83005 | - |
alpha2beta2, 2 * 83005 + 2 * 80000, plasma factor XIII, deduced from amino acid sequence | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| lipoprotein | membrane-bound enzyme of keratocytes is anchored via palmitate and myristate | Homo sapiens |
| additional information | no glycoprotein | Cavia porcellus |
| additional information | no glycoprotein | Mus musculus |
| additional information | no glycoprotein | Homo sapiens |
| additional information | no glycoprotein | Rattus norvegicus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 | structure, function, evolution | Cavia porcellus | |
| protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 | structure, function, evolution | Mus musculus | |
| protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 | structure, function, evolution | Homo sapiens | |
| protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 | structure, function, evolution | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| endothelium | - |
Homo sapiens | - |
| epidermis | - |
Cavia porcellus | - |
| epidermis | - |
Mus musculus | - |
| epidermis | callus, keratinocytes | Homo sapiens | - |
| hair follicle | - |
Cavia porcellus | - |
| hair follicle | - |
Mus musculus | - |
| hair follicle | outer root shear cells | Homo sapiens | - |
| hepatocyte | - |
Rattus norvegicus | - |
| liver | - |
Cavia porcellus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| macrophage | - |
Mus musculus | - |
| additional information | tissue distribution | Cavia porcellus | - |
| additional information | tissue distribution | Mus musculus | - |
| additional information | tissue distribution | Homo sapiens | - |
| additional information | tissue distribution | Rattus norvegicus | - |
| placenta | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| protein-bound gamma-glutamine + alkylamine | substrate fibronectin | Cavia porcellus | protein N5-alkylglutamine + NH3 | resulting bonds are covalent and stable to proteolysis | ? | |
| protein-bound gamma-glutamine + alkylamine | substrate fibronectin | Mus musculus | protein N5-alkylglutamine + NH3 | resulting bonds are covalent and stable to proteolysis | ? | |
| protein-bound gamma-glutamine + alkylamine | substrate fibronectin | Homo sapiens | protein N5-alkylglutamine + NH3 | resulting bonds are covalent and stable to proteolysis | ? | |
| protein-bound gamma-glutamine + alkylamine | substrate fibronectin | Rattus norvegicus | protein N5-alkylglutamine + NH3 | resulting bonds are covalent and stable to proteolysis | ? | |
| protein-bound gamma-glutamine + alkylamine | catalyzes post-translational protein modifications by transamidation of glutamine residues | Cavia porcellus | protein N5-alkylglutamine + NH3 | resulting bonds are covalent and stable to proteolysis | ? | |
| protein-bound gamma-glutamine + alkylamine | catalyzes post-translational protein modifications by transamidation of glutamine residues | Mus musculus | protein N5-alkylglutamine + NH3 | resulting bonds are covalent and stable to proteolysis | ? | |
| protein-bound gamma-glutamine + alkylamine | catalyzes post-translational protein modifications by transamidation of glutamine residues | Homo sapiens | protein N5-alkylglutamine + NH3 | resulting bonds are covalent and stable to proteolysis | ? | |
| protein-bound gamma-glutamine + alkylamine | catalyzes post-translational protein modifications by transamidation of glutamine residues | Rattus norvegicus | protein N5-alkylglutamine + NH3 | resulting bonds are covalent and stable to proteolysis | ? | |
| protein-bound gamma-glutamine + alkylamine | forms intramolecular isopeptide bonds between fibrin molecules | Cavia porcellus | protein N5-alkylglutamine + NH3 | resulting bonds are covalent and stable to proteolysis | ? | |
| protein-bound gamma-glutamine + alkylamine | forms intramolecular isopeptide bonds between fibrin molecules | Mus musculus | protein N5-alkylglutamine + NH3 | resulting bonds are covalent and stable to proteolysis | ? | |
| protein-bound gamma-glutamine + alkylamine | forms intramolecular isopeptide bonds between fibrin molecules | Homo sapiens | protein N5-alkylglutamine + NH3 | resulting bonds are covalent and stable to proteolysis | ? | |
| protein-bound gamma-glutamine + alkylamine | forms intramolecular isopeptide bonds between fibrin molecules | Rattus norvegicus | protein N5-alkylglutamine + NH3 | resulting bonds are covalent and stable to proteolysis | ? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | zymogens of plasma and platelet-coagulation factor XIIIa with different subunit structure: alpha2beta2 and alpha2, respectively | Homo sapiens |
| tetramer | alpha2beta2, 2 * 83005 + 2 * 80000, plasma factor XIII, deduced from amino acid sequence | Homo sapiens |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Laki-Lorand factor | - |
Homo sapiens |
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