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Literature summary for 2.3.2.13 extracted from

  • Takahashi, N.; Takahashi, Y.; Putnam, F.W.
    Primary structure of blood coagulation factor XIIIa (fibrinoligase, transglutaminase) from human placenta (1986), Proc. Natl. Acad. Sci. USA, 83, 8019-8023.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
thrombin removes blocked NH2-terminal peptide of factor XIII and unmasks reactive thiol-group at Cys-314 to yield catalytically active factor XIIIa, i.e. fibrinoligase, from inactive zymogen XIII Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
cloning of placenta FXIIIa-gene cDNA Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+ requirement Homo sapiens
Ca2+ Cys-thiol active binding-site identified Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
83005
-
x * 83005, alpha subunit of placental factor XIIIa, deduced from amino acid sequence Homo sapiens
83010
-
primary structure Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
protein-bound gamma-glutamine + alkylamine Homo sapiens last enzyme in blood coagulation forming intermolecular gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules protein N5-alkylglutamine + NH3
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information no glycoprotein Homo sapiens

Reaction

Reaction Comment Organism Reaction ID
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 mechanism and structure Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma identical with enzyme from placenta or platelets Homo sapiens
-
blood platelet identical with enzyme from plasma Homo sapiens
-
blood platelet placenta Homo sapiens
-
placenta identical with enzyme from plasma Homo sapiens
-
placenta platelets Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
protein-bound gamma-glutamine + alkylamine substrates are coagulation factor V, alpha2-macroglobulin, platelet myosin, actin Homo sapiens protein N5-alkylglutamine + NH3
-
?
protein-bound gamma-glutamine + alkylamine substrate fibronectin Homo sapiens protein N5-alkylglutamine + NH3
-
?
protein-bound gamma-glutamine + alkylamine forms intramolecular isopeptide bonds between fibrin molecules Homo sapiens protein N5-alkylglutamine + NH3
-
?
protein-bound gamma-glutamine + alkylamine last enzyme in blood coagulation forming intermolecular gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules Homo sapiens protein N5-alkylglutamine + NH3
-
?

Subunits

Subunits Comment Organism
? x * 83005, alpha subunit of placental factor XIIIa, deduced from amino acid sequence Homo sapiens