Activating Compound | Comment | Organism | Structure |
---|---|---|---|
thrombin | removes blocked NH2-terminal peptide of factor XIII and unmasks reactive thiol-group at Cys-314 to yield catalytically active factor XIIIa, i.e. fibrinoligase, from inactive zymogen XIII | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
cloning of placenta FXIIIa-gene cDNA | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | requirement | Homo sapiens | |
Ca2+ | Cys-thiol active binding-site identified | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
83005 | - |
x * 83005, alpha subunit of placental factor XIIIa, deduced from amino acid sequence | Homo sapiens |
83010 | - |
primary structure | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
protein-bound gamma-glutamine + alkylamine | Homo sapiens | last enzyme in blood coagulation forming intermolecular gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules | protein N5-alkylglutamine + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
additional information | no glycoprotein | Homo sapiens |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
protein glutamine + alkylamine = protein N5-alkylglutamine + NH3 | mechanism and structure | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | identical with enzyme from placenta or platelets | Homo sapiens | - |
blood platelet | identical with enzyme from plasma | Homo sapiens | - |
blood platelet | placenta | Homo sapiens | - |
placenta | identical with enzyme from plasma | Homo sapiens | - |
placenta | platelets | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
protein-bound gamma-glutamine + alkylamine | substrates are coagulation factor V, alpha2-macroglobulin, platelet myosin, actin | Homo sapiens | protein N5-alkylglutamine + NH3 | - |
? | |
protein-bound gamma-glutamine + alkylamine | substrate fibronectin | Homo sapiens | protein N5-alkylglutamine + NH3 | - |
? | |
protein-bound gamma-glutamine + alkylamine | forms intramolecular isopeptide bonds between fibrin molecules | Homo sapiens | protein N5-alkylglutamine + NH3 | - |
? | |
protein-bound gamma-glutamine + alkylamine | last enzyme in blood coagulation forming intermolecular gamma-glutamyl-epsilon-lysine crosslinks between fibrin molecules | Homo sapiens | protein N5-alkylglutamine + NH3 | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 83005, alpha subunit of placental factor XIIIa, deduced from amino acid sequence | Homo sapiens |