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Literature summary for 2.3.2.12 extracted from

  • Kargas, V.; Castro-Hartmann, P.; Escudero-Urquijo, N.; Dent, K.; Hilcenko, C.; Sailer, C.; Zisser, G.; Marques-Carvalho, M.J.; Pellegrino, S.; Wawiorka, L.; Freund, S.M.; Wagstaff, J.L.; Andreeva, A.; Faille, A.; Chen, E.; Stengel, F.; Bergler, H.; Warren, A.J.
    Mechanism of completion of peptidyltransferase centre assembly in eukaryotes (2019), eLife, 8, e44904 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.3.2.12

Localization

Localization Comment Organism GeneOntology No. Textmining
ribosome
-
 Escherichia coli 5840
-
ribosome
-
 Thermus thermophilus 5840
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
peptidyl-tRNA1 + aminoacyl-tRNA2 Escherichia coli
-
 tRNA1 + peptidyl(aminoacyl-tRNA2)
-
 ?
peptidyl-tRNA1 + aminoacyl-tRNA2 Thermus thermophilus
-
 tRNA1 + peptidyl(aminoacyl-tRNA2)
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Thermus thermophilus Q5SHZ2
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
peptidyl-tRNA1 + aminoacyl-tRNA2
-
 Escherichia coli tRNA1 + peptidyl(aminoacyl-tRNA2)
-
 ?
peptidyl-tRNA1 + aminoacyl-tRNA2
-
 Thermus thermophilus tRNA1 + peptidyl(aminoacyl-tRNA2)
-
 ?

Synonyms

Synonyms Comment Organism
ArfB
-
 Escherichia coli
peptidyltransferase centre
-
 Escherichia coli
peptidyltransferase centre
-
 Thermus thermophilus
PTH
-
 Thermus thermophilus

General Information

General Information Comment Organism
metabolism mechanism of peptidyltransferase centre (PTC) completion, overview. Requirement of the universally conserved Gly-Gly-Gln (GGQ) tripeptide in the highly conserved peptidyl transferase center suggesting that the reported conformation is likely shared during termination of protein synthesis in all domains of life Escherichia coli
metabolism mechanism of peptidyltransferase centre (PTC) completion, overview. Requirement of the universally conserved Gly-Gly-Gln (GGQ) tripeptide in the highly conserved peptidyl transferase center suggesting that the reported conformation is likely shared during termination of protein synthesis in all domains of life Thermus thermophilus
additional information the enzyme is part of the peptidyl transferase center (PTC), conformation of methylated-GGQ in the peptidyl transferase center of the ribosome during canonical translational termination and co-translation quality control, structure modeling, overview Escherichia coli
additional information the enzyme is part of the peptidyl transferase center (PTC), conformation of methylated-GGQ in the peptidyl transferase center of the ribosome during canonical translational termination and co-translation quality control, structure modeling, overview Thermus thermophilus