Literature summary for 2.3.2.12 extracted from

Lecoq, L.; Dubee, V.; Triboulet, S.; Bougault, C.; Hugonnet, J.E.; Arthur, M.; Simorre, J.P.
Structure of Enterococcus faecium L,D-transpeptidase acylated by ertapenem provides insight into the inactivation mechanism (2013), ACS Chem. Biol., 8, 1140-1146.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed in Escherichia coli BL21(DE3) cells	Enterococcus faecium

Inhibitors

Inhibitors	Comment	Organism	Structure
ertapenem	-	Enterococcus faecium

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	contains zinc	Enterococcus faecium

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
peptidyl-tRNA1 + aminoacyl-tRNA2	Enterococcus faecium	the enzyme forms L-Lys3->D-iAsn-L-Lys3 cross-links following cleavage of the L-Lys3-D-Ala4 peptide bond of the donor stem tetrapeptide	tRNA1 + peptidyl(aminoacyl-tRNA2)	-	?

Organism

Organism	UniProt	Comment	Textmining
Enterococcus faecium	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
metal affinity column chromatography and gel filtration	Enterococcus faecium

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
peptidyl-tRNA1 + aminoacyl-tRNA2	the enzyme forms L-Lys3->D-iAsn-L-Lys3 cross-links following cleavage of the L-Lys3-D-Ala4 peptide bond of the donor stem tetrapeptide	Enterococcus faecium	tRNA1 + peptidyl(aminoacyl-tRNA2)	-	?

Synonyms

Synonyms	Comment	Organism
L,D-transpeptidase	-	Enterococcus faecium
LDT	-	Enterococcus faecium

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Release 2023.1 (January 2023)