Literature summary for 2.3.2.12 extracted from

Burakovsky, D.E.; Sergiev, P.V.; Steblyanko, M.A.; Konevega, A.L.; Bogdanov, A.A.; Dontsova, O.A.
The structure of helix 89 of 23S rRNA is important for peptidyl transferase function of Escherichia coli ribosome (2011), FEBS Lett., 585, 3073-3078.

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Protein Variants

Protein Variants	Comment	Organism
additional information	the lethal mutation UU2492-3C affects the function of ribosomal peptidyl transferase center. Binding of Phe-tRNAPhe to the A site of ribosomes with mutation UU2492-3C is much lower comparing to wild type ribosomes (27% and 77%, respectively). Mutant ribosomes are not able to catalyze peptidyl transfer reaction with puromycin as the A-site substrate	Escherichia coli

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
ribosome	-	Escherichia coli	5840	-

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-Phe-tRNA + puromycin	-	Escherichia coli	tRNA + L-Phe-puromycin	-	?
peptidyl-tRNA1 + alpha-aminoacyl-tRNA2	-	Escherichia coli	tRNA1 + peptidyl-amino-tRNA2	-	?

Synonyms

Synonyms	Comment	Organism
peptidyl transferase	-	Escherichia coli
PTC	peptidyl transferase center	Escherichia coli

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Release 2023.1 (January 2023)