Literature summary for 2.3.2.12 extracted from

Hsiao, C.; Williams, L.D.
A recurrent magnesium-binding motif provides a framework for the ribosomal peptidyl transferase center (2009), Nucleic Acids Res., 37, 3134-3142.

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	the ribosomal peptidyl transferase center is supported by a framework of magnesium microclusters. Common features of Mg2+-microclusters include two paired Mg2+ ions that are chelated by a common bridging phosphate group in the form Mg2+(a)-(O1P-PO2P)-Mg2+(b). This bridging phosphate is part of a 10-membered chelation ring in the form Mg2+(a)-(OP-P-O5'-C5'-C4'-C3'-O3'-P-OP)-Mg2+(a). The two phosphate groups of this 10-membered ring are contributed by adjacent residues along the RNA backbone. Both Mg2+ ions are octahedrally coordinated, but are substantially dehydrated by interactions with additional RNA phosphate groups. The Mg2+-microclusters in the large subunit appear to be highly conserved over evolution	Haloarcula marismortui

Organism

Organism	UniProt	Comment	Textmining
Haloarcula marismortui	-	-	-

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Release 2023.1 (January 2023)