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Literature summary for 2.3.2.12 extracted from
- Kinetics of inhibition of rabbit reticulocyte peptidyltransferase by anisomycin and sparsomycin (1998), Mol. Pharmacol., 53, 1089-1096.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| anisomycin | - |
Oryctolagus cuniculus |  |
| sparsomycin | - |
Oryctolagus cuniculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| ribosome | 80S ribosomes | Oryctolagus cuniculus | 5840 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| reticulocyte | unwashed ribosomes | Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| AcPhe-tRNA + puromycin | AcPhe-tRNA-polyU-80S ribosome complex | Oryctolagus cuniculus | tRNA + AcPhe-puromycin | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
enzyme assay, disk reaction | Oryctolagus cuniculus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00013 | - |
sparsomycin | from the competitive phase of the inhibition | Oryctolagus cuniculus | |
| 0.00022 | - |
sparsomycin | - |
Oryctolagus cuniculus | |
| 0.00067 | - |
anisomycin | - |
Oryctolagus cuniculus | |
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