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Literature summary for 2.3.2.12 extracted from
- Inhibition of ribosomal peptidyltransferase by chloramphenicol. Kinetic studies (1987), Eur. J. Biochem., 164, 53-58.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| chloramphenicol | - |
Escherichia coli |  |
| Tevenel | - |
Escherichia coli | |
| Thiamphenicol | - |
Escherichia coli | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| ribosome | - |
Escherichia coli | 5840 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
B cells | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| AcPhe-tRNA + puromycin | AcPhe-tRNA-polyU-70S ribosome complex | Escherichia coli | tRNA + AcPhe-puromycin | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.000045 | - |
Thiamphenicol | - |
Escherichia coli | |
| 0.00007 | - |
chloramphenicol | initial phase of competitive inhibition | Escherichia coli | |
| 0.00017 | - |
Tevenel | - |
Escherichia coli | |
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